RAB21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030516Biological processregulation of axon extension
GO_0008089Biological processanterograde axonal transport
GO_2000643Biological processpositive regulation of early endosome to late endosome transport
GO_0032482Biological processRab protein signal transduction
GO_0006886Biological processintracellular protein transport
GO_0017157Biological processregulation of exocytosis
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0050821Biological processprotein stabilization
GO_0012506Cellular componentvesicle membrane
GO_0012505Cellular componentendomembrane system
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0031901Cellular componentearly endosome membrane
GO_0098559Cellular componentcytoplasmic side of early endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0032154Cellular componentcleavage furrow
GO_0005768Cellular componentendosome
GO_0032580Cellular componentGolgi cisterna membrane
GO_1904115Cellular componentaxon cytoplasm
GO_0019003Molecular functionGDP binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB21
Protein nameRas-related protein Rab-21
SynonymsKIAA0118
DescriptionFUNCTION: Small GTPase involved in membrane trafficking control . During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis . Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion . Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 . .

AccessionsENST00000261263.5
Q9UL25