CPEB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007616Biological processlong-term memory
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0006412Biological processtranslation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_2000766Biological processnegative regulation of cytoplasmic translation
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0048167Biological processregulation of synaptic plasticity
GO_0060998Biological processregulation of dendritic spine development
GO_0060999Biological processpositive regulation of dendritic spine development
GO_0071230Biological processcellular response to amino acid stimulus
GO_1900248Biological processnegative regulation of cytoplasmic translational elongation
GO_0045727Biological processpositive regulation of translation
GO_0017148Biological processnegative regulation of translation
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0030014Cellular componentCCR4-NOT complex
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0097440Cellular componentapical dendrite
GO_1990124Cellular componentmessenger ribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0043022Molecular functionribosome binding
GO_0000900Molecular functionmRNA regulatory element binding translation repressor activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035613Molecular functionRNA stem-loop binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCPEB3
Protein nameCytoplasmic polyadenylation element binding protein 3, isoform CRA_b (cDNA FLJ45117 fis, clone BRAWH3035403, highly similar to Mus musculus cytoplasmic polyadenylation element binding protein 3 (Cpeb3), mRNA)
Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3)
Cytoplasmic polyadenylation element binding protein 3, isoform CRA_a (cDNA FLJ61637, highly similar to Homo sapiens cytoplasmic polyadenylation element binding protein 3 (CPEB3), mRNA)
SynonymsKIAA0940
hCG_20317
DescriptionFUNCTION: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay . In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance . In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression . .

AccessionsENST00000614585.4 [Q8NE35-1]
Q8NE35
ENST00000265997.5 [Q8NE35-1]
Q5QP71
B3KXC1
ENST00000412050.8 [Q8NE35-2]