Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 33% ± 16% | |
astrocyte | 15 studies | 45% ± 21% | |
glutamatergic neuron | 13 studies | 58% ± 26% | |
oligodendrocyte | 13 studies | 33% ± 13% | |
oligodendrocyte precursor cell | 12 studies | 37% ± 14% | |
microglial cell | 12 studies | 40% ± 11% | |
GABAergic neuron | 11 studies | 60% ± 23% | |
macrophage | 10 studies | 37% ± 13% | |
adipocyte | 8 studies | 24% ± 9% | |
interneuron | 6 studies | 67% ± 22% | |
retinal ganglion cell | 6 studies | 58% ± 17% | |
fibroblast | 6 studies | 27% ± 11% | |
neuron | 5 studies | 46% ± 15% | |
amacrine cell | 5 studies | 45% ± 16% | |
cardiac muscle cell | 5 studies | 47% ± 12% | |
retinal cone cell | 5 studies | 49% ± 16% | |
endothelial cell of lymphatic vessel | 5 studies | 23% ± 4% | |
epithelial cell | 4 studies | 44% ± 28% | |
granule cell | 4 studies | 48% ± 9% | |
dendritic cell | 4 studies | 21% ± 3% | |
retina horizontal cell | 4 studies | 49% ± 11% | |
retinal rod cell | 4 studies | 32% ± 8% | |
myeloid cell | 4 studies | 32% ± 7% | |
monocyte | 4 studies | 30% ± 7% | |
type I pneumocyte | 4 studies | 21% ± 2% | |
smooth muscle cell | 4 studies | 19% ± 3% | |
GABAergic interneuron | 3 studies | 64% ± 6% | |
GABAergic amacrine cell | 3 studies | 52% ± 10% | |
OFF-bipolar cell | 3 studies | 37% ± 10% | |
ON-bipolar cell | 3 studies | 50% ± 8% | |
glycinergic amacrine cell | 3 studies | 50% ± 2% | |
endothelial cell of vascular tree | 3 studies | 24% ± 9% | |
hepatocyte | 3 studies | 54% ± 18% | |
retinal pigment epithelial cell | 3 studies | 42% ± 15% | |
alveolar macrophage | 3 studies | 38% ± 5% | |
ciliated cell | 3 studies | 35% ± 8% | |
respiratory goblet cell | 3 studies | 30% ± 12% | |
type II pneumocyte | 3 studies | 22% ± 3% | |
lymphocyte | 3 studies | 21% ± 4% | |
basal cell | 3 studies | 37% ± 23% | |
mesothelial cell | 3 studies | 33% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 99% | 920.29 | 243 / 245 | 100% | 10.15 | 502 / 502 |
thymus | 100% | 1117.02 | 652 / 653 | 99% | 6.01 | 597 / 605 |
esophagus | 100% | 1041.90 | 1441 / 1445 | 98% | 4.11 | 180 / 183 |
adrenal gland | 99% | 812.43 | 256 / 258 | 99% | 8.35 | 227 / 230 |
brain | 99% | 2337.28 | 2627 / 2642 | 97% | 8.42 | 681 / 705 |
breast | 98% | 735.56 | 451 / 459 | 97% | 4.93 | 1088 / 1118 |
kidney | 99% | 666.65 | 88 / 89 | 97% | 4.35 | 870 / 901 |
pancreas | 99% | 741.37 | 324 / 328 | 97% | 3.04 | 172 / 178 |
ovary | 100% | 813.46 | 180 / 180 | 95% | 3.06 | 407 / 430 |
stomach | 98% | 629.41 | 351 / 359 | 93% | 2.89 | 267 / 286 |
lung | 97% | 595.31 | 559 / 578 | 94% | 2.71 | 1086 / 1155 |
intestine | 99% | 708.71 | 961 / 966 | 91% | 2.34 | 479 / 527 |
liver | 100% | 1555.25 | 225 / 226 | 90% | 3.66 | 365 / 406 |
uterus | 99% | 609.09 | 168 / 170 | 90% | 2.91 | 415 / 459 |
bladder | 100% | 618.05 | 21 / 21 | 80% | 1.81 | 403 / 504 |
skin | 73% | 918.60 | 1315 / 1809 | 62% | 1.26 | 293 / 472 |
muscle | 99% | 2006.63 | 798 / 803 | 0% | 0 | 0 / 0 |
spleen | 99% | 618.02 | 239 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 98% | 663.61 | 1302 / 1335 | 0% | 0 | 0 / 0 |
adipose | 96% | 594.20 | 1154 / 1204 | 0% | 0 | 0 / 0 |
heart | 94% | 728.93 | 807 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 3.59 | 40 / 45 |
lymph node | 0% | 0 | 0 / 0 | 66% | 1.23 | 19 / 29 |
eye | 0% | 0 | 0 / 0 | 50% | 1.12 | 40 / 80 |
peripheral blood | 28% | 117.42 | 262 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007616 | Biological process | long-term memory |
GO_0060213 | Biological process | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
GO_0006412 | Biological process | translation |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_2000766 | Biological process | negative regulation of cytoplasmic translation |
GO_0061158 | Biological process | 3'-UTR-mediated mRNA destabilization |
GO_1900153 | Biological process | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
GO_0048167 | Biological process | regulation of synaptic plasticity |
GO_0060998 | Biological process | regulation of dendritic spine development |
GO_0060999 | Biological process | positive regulation of dendritic spine development |
GO_0071230 | Biological process | cellular response to amino acid stimulus |
GO_1900248 | Biological process | negative regulation of cytoplasmic translational elongation |
GO_0045727 | Biological process | positive regulation of translation |
GO_0017148 | Biological process | negative regulation of translation |
GO_0030496 | Cellular component | midbody |
GO_0005886 | Cellular component | plasma membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0043005 | Cellular component | neuron projection |
GO_0030425 | Cellular component | dendrite |
GO_0030014 | Cellular component | CCR4-NOT complex |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0097440 | Cellular component | apical dendrite |
GO_1990124 | Cellular component | messenger ribonucleoprotein complex |
GO_0005634 | Cellular component | nucleus |
GO_0008135 | Molecular function | translation factor activity, RNA binding |
GO_0043022 | Molecular function | ribosome binding |
GO_0000900 | Molecular function | mRNA regulatory element binding translation repressor activity |
GO_0035925 | Molecular function | mRNA 3'-UTR AU-rich region binding |
GO_0003723 | Molecular function | RNA binding |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
GO_0035613 | Molecular function | RNA stem-loop binding |
GO_0005515 | Molecular function | protein binding |
Gene name | CPEB3 |
Protein name | Cytoplasmic polyadenylation element binding protein 3, isoform CRA_b (cDNA FLJ45117 fis, clone BRAWH3035403, highly similar to Mus musculus cytoplasmic polyadenylation element binding protein 3 (Cpeb3), mRNA) Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3) Cytoplasmic polyadenylation element binding protein 3, isoform CRA_a (cDNA FLJ61637, highly similar to Homo sapiens cytoplasmic polyadenylation element binding protein 3 (CPEB3), mRNA) |
Synonyms | KIAA0940 hCG_20317 |
Description | FUNCTION: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay . In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance . In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression . . |
Accessions | ENST00000614585.4 [Q8NE35-1] Q8NE35 ENST00000265997.5 [Q8NE35-1] Q5QP71 B3KXC1 ENST00000412050.8 [Q8NE35-2] |