CYFIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	31 studies	32% ± 14%	Explore
endothelial cell	21 studies	27% ± 9%	Explore
microglial cell	12 studies	51% ± 23%	Explore
myeloid cell	12 studies	39% ± 14%	Explore
pericyte	11 studies	20% ± 5%	Explore
endothelial cell of lymphatic vessel	10 studies	24% ± 8%	Explore
fibroblast	10 studies	20% ± 3%	Explore
capillary endothelial cell	8 studies	19% ± 5%	Explore
classical monocyte	7 studies	25% ± 9%	Explore
smooth muscle cell	7 studies	19% ± 4%	Explore
dendritic cell	6 studies	25% ± 7%	Explore
type I pneumocyte	5 studies	20% ± 4%	Explore
GABAergic neuron	5 studies	23% ± 12%	Explore
epithelial cell	5 studies	38% ± 17%	Explore
adipocyte	5 studies	19% ± 3%	Explore
conventional dendritic cell	4 studies	27% ± 2%	Explore
glutamatergic neuron	4 studies	27% ± 12%	Explore
basal cell	4 studies	30% ± 15%	Explore
endothelial cell of artery	4 studies	18% ± 2%	Explore
ciliated cell	4 studies	25% ± 7%	Explore
interneuron	4 studies	37% ± 23%	Explore
glomerular endothelial cell	3 studies	24% ± 2%	Explore
neuron	3 studies	28% ± 16%	Explore
monocyte	3 studies	29% ± 8%	Explore
non-classical monocyte	3 studies	22% ± 2%	Explore
tissue-resident macrophage	3 studies	30% ± 5%	Explore
endothelial cell of vascular tree	3 studies	30% ± 11%	Explore
secretory cell	3 studies	22% ± 5%	Explore
abnormal cell	3 studies	24% ± 7%	Explore
alveolar macrophage	3 studies	31% ± 11%	Explore
goblet cell	3 studies	35% ± 21%	Explore
astrocyte	3 studies	31% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	31% ± 10%	Explore
lung	4 studies	26% ± 6%	Explore
adipose	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6979.64	1445 / 1445	100%	59.56	183 / 183
lung	100%	8800.95	578 / 578	100%	50.45	1155 / 1155
stomach	100%	5409.45	359 / 359	100%	46.80	286 / 286
breast	100%	8058.14	459 / 459	100%	61.27	1117 / 1118
intestine	100%	6801.28	966 / 966	100%	48.49	526 / 527
uterus	100%	7135.53	170 / 170	100%	46.95	458 / 459
ovary	100%	5919.27	180 / 180	100%	33.93	429 / 430
prostate	100%	5729.88	245 / 245	100%	55.77	500 / 502
skin	100%	8492.02	1809 / 1809	100%	58.12	470 / 472
bladder	100%	6078.71	21 / 21	99%	44.99	501 / 504
pancreas	100%	4596.34	327 / 328	99%	47.55	177 / 178
kidney	100%	4943.35	89 / 89	99%	44.56	892 / 901
thymus	100%	6239.26	652 / 653	99%	39.94	598 / 605
brain	97%	2993.19	2569 / 2642	99%	60.41	701 / 705
liver	98%	2707.57	222 / 226	96%	23.75	390 / 406
adrenal gland	100%	5433.24	258 / 258	87%	17.21	201 / 230
adipose	100%	8429.80	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9424.13	1335 / 1335	0%	0	0 / 0
spleen	100%	5601.29	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.08	45 / 45
ureter	0%	0	0 / 0	100%	17.66	1 / 1
eye	0%	0	0 / 0	98%	43.59	78 / 80
heart	97%	2742.19	835 / 861	0%	0	0 / 0
muscle	97%	2539.37	775 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	22.39	26 / 29
peripheral blood	58%	1997.19	535 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031641	Biological process	regulation of myelination
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0031529	Biological process	ruffle organization
GO_0045773	Biological process	positive regulation of axon extension
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0051602	Biological process	response to electrical stimulus
GO_0099578	Biological process	regulation of translation at postsynapse, modulating synaptic transmission
GO_0030032	Biological process	lamellipodium assembly
GO_0097484	Biological process	dendrite extension
GO_1905274	Biological process	regulation of modification of postsynaptic actin cytoskeleton
GO_0051388	Biological process	positive regulation of neurotrophin TRK receptor signaling pathway
GO_1900029	Biological process	positive regulation of ruffle assembly
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0006417	Biological process	regulation of translation
GO_1903422	Biological process	negative regulation of synaptic vesicle recycling
GO_1900006	Biological process	positive regulation of dendrite development
GO_0016601	Biological process	Rac protein signal transduction
GO_0048675	Biological process	axon extension
GO_0050890	Biological process	cognition
GO_0008360	Biological process	regulation of cell shape
GO_2000601	Biological process	positive regulation of Arp2/3 complex-mediated actin nucleation
GO_0000902	Biological process	cell morphogenesis
GO_0099563	Biological process	modification of synaptic structure
GO_0017148	Biological process	negative regulation of translation
GO_0007411	Biological process	axon guidance
GO_0001726	Cellular component	ruffle
GO_0090725	Cellular component	peripheral region of growth cone
GO_0005576	Cellular component	extracellular region
GO_0043197	Cellular component	dendritic spine
GO_0035580	Cellular component	specific granule lumen
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0043195	Cellular component	terminal bouton
GO_0032433	Cellular component	filopodium tip
GO_0070062	Cellular component	extracellular exosome
GO_0043025	Cellular component	neuronal cell body
GO_0043005	Cellular component	neuron projection
GO_0034774	Cellular component	secretory granule lumen
GO_0005925	Cellular component	focal adhesion
GO_1904724	Cellular component	tertiary granule lumen
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0044294	Cellular component	dendritic growth cone
GO_0044295	Cellular component	axonal growth cone
GO_0090724	Cellular component	central region of growth cone
GO_0060076	Cellular component	excitatory synapse
GO_0030027	Cellular component	lamellipodium
GO_0031209	Cellular component	SCAR complex
GO_0030371	Molecular function	translation repressor activity
GO_0000340	Molecular function	RNA 7-methylguanosine cap binding
GO_0051015	Molecular function	actin filament binding
GO_0031267	Molecular function	small GTPase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYFIP1
Protein name	Cytoplasmic FMR1 interacting protein 1 Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) Cytoplasmic FMR1-interacting protein Cytoplasmic FMR1-interacting protein 1 Cytoplasmic FMR1 interacting protein 1 isoform A
Synonyms	KIAA0068
Description	FUNCTION: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers. .
Accessions	A0A0G2JR96 ENST00000617928.5 [Q7L576-1] ENST00000626546.1 ENST00000627816.1 A0A087WWL1 ENST00000628954.2 A0A0G2JQT1 ENST00000627204.1 ENST00000561263.2 ENST00000613006.4 ENST00000628747.2 ENST00000617556.4 [Q7L576-2] X5D2F4 A0A087WVZ5 A0A087WWY5 ENST00000672091.1 [Q7L576-1] A0A0G2JRP0 ENST00000610365.4 [Q7L576-1] ENST00000630158.2 Q7L576 A0A0G2JRV9 A0A0G2JRX2 ENST00000612288.2 A0A087WZ89 H0YL50 ENST00000671714.1 [Q7L576-1] ENST00000619037.1 ENST00000622576.1 A0A0G2JRF5 ENST00000625276.2 A0A0G2JQH3 A0A087WU52 ENST00000611832.4

CYFIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review