Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 11 studies | 24% ± 7% | |
glutamatergic neuron | 10 studies | 47% ± 22% | |
retinal ganglion cell | 7 studies | 38% ± 18% | |
endothelial cell | 6 studies | 28% ± 9% | |
GABAergic neuron | 6 studies | 41% ± 15% | |
neuron | 5 studies | 34% ± 17% | |
retinal bipolar neuron | 5 studies | 45% ± 17% | |
interneuron | 5 studies | 32% ± 14% | |
cardiac muscle cell | 4 studies | 19% ± 3% | |
Mueller cell | 4 studies | 19% ± 2% | |
OFF-bipolar cell | 4 studies | 31% ± 4% | |
ON-bipolar cell | 4 studies | 39% ± 12% | |
type I pneumocyte | 4 studies | 27% ± 10% | |
rod bipolar cell | 3 studies | 69% ± 11% | |
hepatocyte | 3 studies | 40% ± 18% | |
granule cell | 3 studies | 33% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 1235.54 | 226 / 226 | 96% | 12.08 | 389 / 406 |
kidney | 100% | 1200.80 | 89 / 89 | 91% | 25.21 | 821 / 901 |
brain | 97% | 1860.06 | 2566 / 2642 | 91% | 8.52 | 640 / 705 |
breast | 100% | 995.48 | 457 / 459 | 57% | 10.04 | 638 / 1118 |
thymus | 100% | 1035.09 | 652 / 653 | 48% | 2.64 | 289 / 605 |
prostate | 84% | 423.04 | 207 / 245 | 59% | 3.25 | 298 / 502 |
bladder | 100% | 1028.67 | 21 / 21 | 36% | 2.53 | 179 / 504 |
lung | 100% | 1292.04 | 578 / 578 | 27% | 1.97 | 307 / 1155 |
uterus | 99% | 2013.22 | 168 / 170 | 22% | 2.14 | 102 / 459 |
adrenal gland | 41% | 146.86 | 107 / 258 | 73% | 10.36 | 168 / 230 |
intestine | 84% | 482.28 | 809 / 966 | 22% | 1.65 | 116 / 527 |
ovary | 99% | 796.58 | 179 / 180 | 4% | 0.14 | 16 / 430 |
spleen | 100% | 1067.53 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 1140.06 | 1203 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 2472.01 | 901 / 929 | 0% | 0 | 0 / 0 |
heart | 96% | 956.75 | 829 / 861 | 0% | 0 | 0 / 0 |
esophagus | 68% | 473.85 | 985 / 1445 | 22% | 1.00 | 41 / 183 |
blood vessel | 78% | 504.42 | 1035 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 70% | 9.04 | 56 / 80 |
stomach | 42% | 193.43 | 150 / 359 | 23% | 1.36 | 65 / 286 |
skin | 49% | 400.59 | 880 / 1809 | 13% | 1.04 | 60 / 472 |
pancreas | 3% | 10.65 | 11 / 328 | 39% | 1.87 | 69 / 178 |
lymph node | 0% | 0 | 0 / 0 | 28% | 0.81 | 8 / 29 |
muscle | 26% | 76.44 | 209 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 9% | 0.35 | 4 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045199 | Biological process | maintenance of epithelial cell apical/basal polarity |
GO_1903361 | Biological process | protein localization to basolateral plasma membrane |
GO_0007269 | Biological process | neurotransmitter secretion |
GO_0048839 | Biological process | inner ear development |
GO_0065003 | Biological process | protein-containing complex assembly |
GO_0006887 | Biological process | exocytosis |
GO_0015031 | Biological process | protein transport |
GO_0048489 | Biological process | synaptic vesicle transport |
GO_0098839 | Cellular component | postsynaptic density membrane |
GO_0098793 | Cellular component | presynapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005911 | Cellular component | cell-cell junction |
GO_0097025 | Cellular component | MPP7-DLG1-LIN7 complex |
GO_0045202 | Cellular component | synapse |
GO_0005923 | Cellular component | bicellular tight junction |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0097016 | Molecular function | L27 domain binding |
GO_0005515 | Molecular function | protein binding |
Gene name | LIN7A |
Protein name | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) Lin-7 homolog A, crumbs cell polarity complex component |
Synonyms | MALS1 VELI1 |
Description | FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. . |
Accessions | ENST00000552093.1 ENST00000552864.6 H0YI92 J3KN23 ENST00000549417.5 H0YIA8 ENST00000261203.7 O14910 |