STAC3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of STAC3 at tissue level.

III. Associated gene sets

GO_0048741Biological processskeletal muscle fiber development
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_1901387Biological processpositive regulation of voltage-gated calcium channel activity
GO_0003009Biological processskeletal muscle contraction
GO_0007274Biological processneuromuscular synaptic transmission
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0030315Cellular componentT-tubule
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSTAC3
Protein nameSH3 and cysteine rich domain 3
SH3 and cysteine-rich domain-containing protein 3
Synonyms
DescriptionFUNCTION: Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels . Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C . .

AccessionsG3V2L9
G3V5D4
ENST00000557176.5
ENST00000332782.7 [Q96MF2-1]
ENST00000553489.1
ENST00000546246.2 [Q96MF2-3]
Q96MF2
ENST00000554578.5 [Q96MF2-2]