TIAM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	14 studies	37% ± 16%	Explore
oligodendrocyte precursor cell	14 studies	44% ± 17%	Explore
microglial cell	13 studies	44% ± 14%	Explore
astrocyte	12 studies	35% ± 16%	Explore
GABAergic neuron	11 studies	56% ± 26%	Explore
glutamatergic neuron	10 studies	50% ± 18%	Explore
macrophage	9 studies	26% ± 10%	Explore
endothelial cell	9 studies	36% ± 18%	Explore
regulatory T cell	9 studies	18% ± 3%	Explore
fibroblast	8 studies	25% ± 11%	Explore
mast cell	7 studies	25% ± 9%	Explore
neuron	6 studies	31% ± 14%	Explore
interneuron	6 studies	69% ± 18%	Explore
retina horizontal cell	6 studies	55% ± 23%	Explore
epithelial cell	5 studies	33% ± 23%	Explore
amacrine cell	5 studies	48% ± 18%	Explore
granule cell	4 studies	78% ± 17%	Explore
dendritic cell	4 studies	23% ± 8%	Explore
myeloid cell	4 studies	28% ± 19%	Explore
Mueller cell	4 studies	48% ± 8%	Explore
monocyte	4 studies	37% ± 8%	Explore
endothelial cell of sinusoid	3 studies	32% ± 12%	Explore
T cell	3 studies	17% ± 0%	Explore
non-classical monocyte	3 studies	25% ± 5%	Explore
GABAergic interneuron	3 studies	64% ± 14%	Explore
mesothelial cell	3 studies	24% ± 7%	Explore
ciliated cell	3 studies	20% ± 4%	Explore
GABAergic amacrine cell	3 studies	52% ± 8%	Explore
glycinergic amacrine cell	3 studies	45% ± 8%	Explore
T follicular helper cell	3 studies	20% ± 0%	Explore
hepatocyte	3 studies	55% ± 18%	Explore
alveolar macrophage	3 studies	40% ± 8%	Explore
basal cell	3 studies	41% ± 30%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	42% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	10609.71	2634 / 2642	100%	23.32	702 / 705
uterus	99%	2237.17	169 / 170	88%	13.88	404 / 459
breast	83%	925.58	380 / 459	91%	11.00	1012 / 1118
prostate	98%	1472.58	239 / 245	72%	4.55	361 / 502
skin	88%	3461.17	1597 / 1809	77%	10.52	365 / 472
bladder	90%	1499.57	19 / 21	72%	10.92	361 / 504
lung	79%	927.09	459 / 578	70%	6.71	814 / 1155
ovary	42%	401.38	75 / 180	90%	9.82	387 / 430
esophagus	56%	2385.43	811 / 1445	73%	12.23	133 / 183
adrenal gland	52%	646.44	133 / 258	72%	36.73	166 / 230
thymus	25%	195.88	165 / 653	89%	19.57	536 / 605
kidney	53%	523.42	47 / 89	49%	3.01	439 / 901
tonsil	0%	0	0 / 0	100%	18.27	45 / 45
ureter	0%	0	0 / 0	100%	12.35	1 / 1
intestine	72%	679.04	699 / 966	20%	1.50	108 / 527
adipose	89%	1135.41	1068 / 1204	0%	0	0 / 0
spleen	88%	768.59	213 / 241	0%	0	0 / 0
pancreas	5%	39.56	17 / 328	76%	6.77	135 / 178
liver	67%	561.62	151 / 226	14%	0.73	55 / 406
lymph node	0%	0	0 / 0	69%	7.34	20 / 29
stomach	17%	121.39	61 / 359	23%	1.21	67 / 286
heart	36%	339.11	306 / 861	0%	0	0 / 0
peripheral blood	28%	241.09	258 / 929	0%	0	0 / 0
blood vessel	14%	123.85	189 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	14%	0.66	11 / 80
muscle	1%	4.84	6 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0061003	Biological process	positive regulation of dendritic spine morphogenesis
GO_0090630	Biological process	activation of GTPase activity
GO_0007160	Biological process	cell-matrix adhesion
GO_0032092	Biological process	positive regulation of protein binding
GO_1905274	Biological process	regulation of modification of postsynaptic actin cytoskeleton
GO_0051056	Biological process	regulation of small GTPase mediated signal transduction
GO_0003300	Biological process	cardiac muscle hypertrophy
GO_0065003	Biological process	protein-containing complex assembly
GO_2000050	Biological process	regulation of non-canonical Wnt signaling pathway
GO_0042220	Biological process	response to cocaine
GO_0030335	Biological process	positive regulation of cell migration
GO_0061178	Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0016601	Biological process	Rac protein signal transduction
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0060071	Biological process	Wnt signaling pathway, planar cell polarity pathway
GO_1990138	Biological process	neuron projection extension
GO_1904338	Biological process	regulation of dopaminergic neuron differentiation
GO_0010717	Biological process	regulation of epithelial to mesenchymal transition
GO_0072657	Biological process	protein localization to membrane
GO_0016477	Biological process	cell migration
GO_1904268	Biological process	positive regulation of Schwann cell chemotaxis
GO_0032587	Cellular component	ruffle membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0043197	Cellular component	dendritic spine
GO_0043025	Cellular component	neuronal cell body
GO_0044304	Cellular component	main axon
GO_0044291	Cellular component	cell-cell contact zone
GO_0005911	Cellular component	cell-cell junction
GO_0099147	Cellular component	extrinsic component of postsynaptic density membrane
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0044295	Cellular component	axonal growth cone
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0008289	Molecular function	lipid binding
GO_0019900	Molecular function	kinase binding
GO_0008017	Molecular function	microtubule binding
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding

IV. Literature review

[source]

Gene name	TIAM1
Protein name	TIAM Rac1 associated GEF 1 T-cell lymphoma invasion and metastasis 1 (TIAM1) Rho guanine nucleotide exchange factor TIAM1 Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Synonyms	hCG_401145
Description	FUNCTION: Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. .
Accessions	ENST00000286827.7 [Q13009-1] ENST00000698169.1 H7C079 Q13009 ENST00000455508.2 [Q13009-2] ENST00000541036.6 [Q13009-1] A0A1B0GW57 A0A8V8TN84 A0A2X0TW27 C9JMB5 ENST00000423206.5 ENST00000455508 ENST00000636887.1

TIAM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review