MAPK8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0007254Biological processJNK cascade
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0034614Biological processcellular response to reactive oxygen species
GO_0071260Biological processcellular response to mechanical stimulus
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0031343Biological processpositive regulation of cell killing
GO_0010628Biological processpositive regulation of gene expression
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0032880Biological processregulation of protein localization
GO_0071276Biological processcellular response to cadmium ion
GO_0009411Biological processresponse to UV
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0042752Biological processregulation of circadian rhythm
GO_0051403Biological processstress-activated MAPK cascade
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0034599Biological processcellular response to oxidative stress
GO_0043066Biological processnegative regulation of apoptotic process
GO_0034198Biological processcellular response to amino acid starvation
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0090398Biological processcellular senescence
GO_0009612Biological processresponse to mechanical stimulus
GO_0016241Biological processregulation of macroautophagy
GO_0006468Biological processprotein phosphorylation
GO_0031281Biological processpositive regulation of cyclase activity
GO_0032091Biological processnegative regulation of protein binding
GO_0007258Biological processJUN phosphorylation
GO_0006979Biological processresponse to oxidative stress
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048511Biological processrhythmic process
GO_0097441Cellular componentbasal dendrite
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0035033Molecular functionhistone deacetylase regulator activity
GO_0019899Molecular functionenzyme binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004705Molecular functionJUN kinase activity
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMAPK8
Protein nameStress-activated protein kinase JNK (EC 2.7.11.24)
Mitogen-activated protein kinase 8
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
SynonymsPRKM8
SAPK1
hCG_23734
JNK1
SAPK1C
DescriptionFUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway . In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity . Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins . Loss of this interaction abrogates the acetylation required for replication initiation . Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 . In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation . Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy . Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH . Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock . Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity . Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 . In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly . Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity . Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome . .; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. .

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. .

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. .

FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. .

AccessionsENST00000374189.6 [P45983-1]
P45983
ENST00000374179.8 [P45983-3]
ENST00000360332.7 [P45983-5]
ENST00000432379.5
ENST00000426557.5
ENST00000429041.6
A1L4K2
A0A3B3IRW7
C9J762
ENST00000395611.7 [P45983-4]
ENST00000374176.8 [P45983-4]
B5BUB8
ENST00000476134.1
ENST00000374182.7 [P45983-2]
C9JWQ4