Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 35% ± 15% | |
astrocyte | 18 studies | 40% ± 18% | |
oligodendrocyte precursor cell | 13 studies | 46% ± 18% | |
glutamatergic neuron | 12 studies | 57% ± 23% | |
microglial cell | 12 studies | 28% ± 11% | |
oligodendrocyte | 12 studies | 34% ± 11% | |
GABAergic neuron | 11 studies | 54% ± 23% | |
fibroblast | 11 studies | 28% ± 10% | |
adipocyte | 9 studies | 30% ± 9% | |
epithelial cell | 8 studies | 35% ± 15% | |
macrophage | 8 studies | 32% ± 13% | |
pericyte | 7 studies | 33% ± 14% | |
smooth muscle cell | 7 studies | 26% ± 5% | |
neuron | 6 studies | 55% ± 16% | |
interneuron | 6 studies | 67% ± 17% | |
retina horizontal cell | 6 studies | 48% ± 23% | |
amacrine cell | 5 studies | 32% ± 13% | |
cardiac muscle cell | 5 studies | 27% ± 8% | |
ciliated cell | 5 studies | 25% ± 8% | |
endothelial cell of lymphatic vessel | 5 studies | 31% ± 7% | |
dendritic cell | 5 studies | 22% ± 4% | |
type I pneumocyte | 5 studies | 31% ± 12% | |
type II pneumocyte | 5 studies | 34% ± 9% | |
granule cell | 4 studies | 47% ± 10% | |
retinal ganglion cell | 4 studies | 40% ± 21% | |
plasma cell | 4 studies | 25% ± 7% | |
retinal bipolar neuron | 4 studies | 44% ± 23% | |
mast cell | 4 studies | 22% ± 5% | |
Mueller cell | 4 studies | 36% ± 11% | |
retinal cone cell | 4 studies | 34% ± 10% | |
retinal rod cell | 4 studies | 41% ± 9% | |
myeloid cell | 4 studies | 21% ± 4% | |
monocyte | 4 studies | 26% ± 6% | |
club cell | 4 studies | 33% ± 11% | |
basal cell | 4 studies | 34% ± 21% | |
GABAergic interneuron | 3 studies | 56% ± 7% | |
glial cell | 3 studies | 27% ± 13% | |
progenitor cell | 3 studies | 44% ± 12% | |
GABAergic amacrine cell | 3 studies | 45% ± 12% | |
ON-bipolar cell | 3 studies | 52% ± 22% | |
glycinergic amacrine cell | 3 studies | 40% ± 14% | |
rod bipolar cell | 3 studies | 59% ± 23% | |
endothelial cell of vascular tree | 3 studies | 29% ± 14% | |
hepatocyte | 3 studies | 45% ± 15% | |
retinal pigment epithelial cell | 3 studies | 33% ± 23% | |
ependymal cell | 3 studies | 33% ± 16% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 22% ± 5% | |
T cell | 3 studies | 22% ± 1% | |
alveolar macrophage | 3 studies | 29% ± 9% | |
respiratory goblet cell | 3 studies | 32% ± 11% | |
lymphocyte | 3 studies | 26% ± 9% | |
mesothelial cell | 3 studies | 32% ± 3% | |
mucus secreting cell | 3 studies | 27% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1880.30 | 1445 / 1445 | 100% | 13.42 | 183 / 183 |
lung | 100% | 2055.94 | 578 / 578 | 100% | 11.30 | 1155 / 1155 |
ovary | 100% | 2922.79 | 180 / 180 | 100% | 10.83 | 430 / 430 |
prostate | 100% | 2120.69 | 245 / 245 | 100% | 11.71 | 502 / 502 |
brain | 100% | 2652.51 | 2639 / 2642 | 100% | 16.90 | 705 / 705 |
breast | 100% | 2572.70 | 459 / 459 | 100% | 15.15 | 1116 / 1118 |
bladder | 100% | 1776.76 | 21 / 21 | 100% | 10.38 | 503 / 504 |
uterus | 100% | 2286.69 | 170 / 170 | 100% | 12.08 | 458 / 459 |
thymus | 100% | 3178.95 | 653 / 653 | 100% | 13.25 | 603 / 605 |
stomach | 100% | 1598.00 | 359 / 359 | 100% | 10.50 | 285 / 286 |
intestine | 100% | 2211.06 | 966 / 966 | 100% | 10.32 | 525 / 527 |
kidney | 100% | 1909.76 | 89 / 89 | 99% | 9.72 | 896 / 901 |
pancreas | 100% | 1177.73 | 328 / 328 | 99% | 10.11 | 177 / 178 |
liver | 100% | 1448.04 | 226 / 226 | 99% | 7.02 | 401 / 406 |
adrenal gland | 100% | 1653.33 | 258 / 258 | 97% | 9.01 | 224 / 230 |
skin | 100% | 1851.55 | 1809 / 1809 | 91% | 6.50 | 429 / 472 |
adipose | 100% | 2116.71 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 6.21 | 29 / 29 |
spleen | 100% | 1789.57 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.52 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.37 | 1 / 1 |
blood vessel | 100% | 1737.97 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1524.68 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1129.36 | 846 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 75% | 4.32 | 60 / 80 |
peripheral blood | 65% | 975.81 | 601 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097009 | Biological process | energy homeostasis |
GO_0007254 | Biological process | JNK cascade |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0034614 | Biological process | cellular response to reactive oxygen species |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0051247 | Biological process | positive regulation of protein metabolic process |
GO_0031343 | Biological process | positive regulation of cell killing |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
GO_0032880 | Biological process | regulation of protein localization |
GO_0071276 | Biological process | cellular response to cadmium ion |
GO_0009411 | Biological process | response to UV |
GO_0038095 | Biological process | Fc-epsilon receptor signaling pathway |
GO_0042752 | Biological process | regulation of circadian rhythm |
GO_0051403 | Biological process | stress-activated MAPK cascade |
GO_1900227 | Biological process | positive regulation of NLRP3 inflammasome complex assembly |
GO_0034599 | Biological process | cellular response to oxidative stress |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0034198 | Biological process | cellular response to amino acid starvation |
GO_0071222 | Biological process | cellular response to lipopolysaccharide |
GO_0090398 | Biological process | cellular senescence |
GO_0009612 | Biological process | response to mechanical stimulus |
GO_0016241 | Biological process | regulation of macroautophagy |
GO_0006468 | Biological process | protein phosphorylation |
GO_0031281 | Biological process | positive regulation of cyclase activity |
GO_0032091 | Biological process | negative regulation of protein binding |
GO_0007258 | Biological process | JUN phosphorylation |
GO_0006979 | Biological process | response to oxidative stress |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0048511 | Biological process | rhythmic process |
GO_0097441 | Cellular component | basal dendrite |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0005634 | Cellular component | nucleus |
GO_0035033 | Molecular function | histone deacetylase regulator activity |
GO_0019899 | Molecular function | enzyme binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0019903 | Molecular function | protein phosphatase binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004705 | Molecular function | JUN kinase activity |
GO_0120283 | Molecular function | protein serine/threonine kinase binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0042826 | Molecular function | histone deacetylase binding |
Gene name | MAPK8 |
Protein name | Stress-activated protein kinase JNK (EC 2.7.11.24) Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) |
Synonyms | PRKM8 SAPK1 hCG_23734 JNK1 SAPK1C |
Description | FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway . In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity . Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins . Loss of this interaction abrogates the acetylation required for replication initiation . Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1 . In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation . Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy . Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (By similarity). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (By similarity). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH . Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock . Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity . Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 . In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly . Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity . Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome . .; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. . FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. . FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. . FUNCTION: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. . |
Accessions | ENST00000374189.6 [P45983-1] P45983 ENST00000374179.8 [P45983-3] ENST00000360332.7 [P45983-5] ENST00000432379.5 ENST00000426557.5 ENST00000429041.6 A1L4K2 A0A3B3IRW7 C9J762 ENST00000395611.7 [P45983-4] ENST00000374176.8 [P45983-4] B5BUB8 ENST00000476134.1 ENST00000374182.7 [P45983-2] C9JWQ4 |