SLC5A7 | OmnibusX

Name	Number of supported studies	Average coverage
neuron	4 studies	30% ± 11%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC5A7 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	95%	288.52	20 / 21	23%	0.97	115 / 504
ureter	0%	0	0 / 0	100%	1.75	1 / 1
adrenal gland	70%	99.42	181 / 258	28%	2.69	65 / 230
intestine	89%	415.08	864 / 966	1%	0.03	7 / 527
prostate	78%	97.27	191 / 245	1%	0.01	4 / 502
kidney	76%	48.26	68 / 89	1%	0.14	9 / 901
esophagus	68%	221.34	985 / 1445	2%	0.16	4 / 183
thymus	63%	42.32	409 / 653	7%	0.38	43 / 605
stomach	58%	118.78	207 / 359	5%	0.11	14 / 286
uterus	51%	53.93	86 / 170	4%	0.17	18 / 459
lung	38%	23.34	221 / 578	12%	1.03	135 / 1155
heart	37%	29.21	317 / 861	0%	0	0 / 0
brain	34%	126.58	886 / 2642	0%	0.01	2 / 705
breast	28%	25.09	128 / 459	5%	0.42	53 / 1118
ovary	29%	22.79	53 / 180	0%	0.05	2 / 430
adipose	23%	12.59	276 / 1204	0%	0	0 / 0
blood vessel	18%	9.22	244 / 1335	0%	0	0 / 0
pancreas	7%	2.88	23 / 328	11%	0.19	19 / 178
tonsil	0%	0	0 / 0	9%	0.42	4 / 45
liver	4%	1.21	9 / 226	0%	0.01	1 / 406
skin	3%	1.04	52 / 1809	0%	0.00	1 / 472
spleen	1%	0.59	2 / 241	0%	0	0 / 0
muscle	0%	0.04	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0001701	Biological process	in utero embryonic development
GO_0055085	Biological process	transmembrane transport
GO_0008292	Biological process	acetylcholine biosynthetic process
GO_0007274	Biological process	neuromuscular synaptic transmission
GO_0006814	Biological process	sodium ion transport
GO_0006836	Biological process	neurotransmitter transport
GO_0015871	Biological process	choline transport
GO_0007271	Biological process	synaptic transmission, cholinergic
GO_0005886	Cellular component	plasma membrane
GO_0031594	Cellular component	neuromuscular junction
GO_0016020	Cellular component	membrane
GO_0043204	Cellular component	perikaryon
GO_0031901	Cellular component	early endosome membrane
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0042734	Cellular component	presynaptic membrane
GO_0030425	Cellular component	dendrite
GO_0045202	Cellular component	synapse
GO_0030424	Cellular component	axon
GO_0033265	Molecular function	choline binding
GO_0015220	Molecular function	choline transmembrane transporter activity
GO_0005307	Molecular function	choline:sodium symporter activity

Gene name	SLC5A7
Protein name	SLC5A7 protein High affinity choline transporter 1 (hCHT1) (Hemicholinium-3-sensitive choline transporter) (CHT) (Solute carrier family 5 member 7)
Synonyms	CHT1
Description	FUNCTION: High-affinity Na(+)-coupled choline transmembrane symporter . Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry . Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion . Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release . SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials . Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity . .
Accessions	Q9GZV3 ENST00000264047.3 ENST00000409059.5 Q2T9H3

SLC5A7 report