I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 10 studies | 35% ± 20% | |
| neuron | 3 studies | 20% ± 6% | |
| GABAergic neuron | 3 studies | 36% ± 8% | |
| granule cell | 3 studies | 33% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 10 studies | 35% ± 20% | |
| neuron | 3 studies | 20% ± 6% | |
| GABAergic neuron | 3 studies | 36% ± 8% | |
| granule cell | 3 studies | 33% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 33% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 95% | 8217.55 | 2498 / 2642 | 89% | 18.59 | 627 / 705 |
| pancreas | 83% | 485.67 | 271 / 328 | 57% | 5.00 | 101 / 178 |
| uterus | 82% | 1113.88 | 139 / 170 | 32% | 2.48 | 149 / 459 |
| adrenal gland | 12% | 112.77 | 32 / 258 | 77% | 37.58 | 176 / 230 |
| intestine | 66% | 860.44 | 638 / 966 | 13% | 0.40 | 71 / 527 |
| esophagus | 50% | 339.64 | 718 / 1445 | 19% | 0.49 | 34 / 183 |
| bladder | 43% | 406.90 | 9 / 21 | 24% | 0.73 | 121 / 504 |
| prostate | 26% | 138.74 | 64 / 245 | 30% | 0.66 | 151 / 502 |
| stomach | 29% | 228.74 | 104 / 359 | 21% | 0.82 | 61 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 22% | 1.21 | 10 / 45 |
| eye | 0% | 0 | 0 / 0 | 21% | 0.48 | 17 / 80 |
| lung | 0% | 1.58 | 1 / 578 | 18% | 0.83 | 209 / 1155 |
| breast | 0% | 0 | 0 / 459 | 18% | 1.12 | 198 / 1118 |
| ovary | 3% | 11.19 | 5 / 180 | 11% | 0.27 | 47 / 430 |
| skin | 0% | 0.63 | 3 / 1809 | 11% | 0.28 | 53 / 472 |
| kidney | 0% | 0 | 0 / 89 | 6% | 0.14 | 54 / 901 |
| blood vessel | 3% | 10.01 | 36 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.44 | 1 / 653 | 2% | 0.05 | 14 / 605 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.05 | 5 / 406 |
| muscle | 1% | 8.87 | 9 / 803 | 0% | 0 | 0 / 0 |
| spleen | 0% | 1.71 | 1 / 241 | 0% | 0 | 0 / 0 |
| adipose | 0% | 1.34 | 4 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 4.00 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051480 | Biological process | regulation of cytosolic calcium ion concentration |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0002931 | Biological process | response to ischemia |
| GO_0099566 | Biological process | regulation of postsynaptic cytosolic calcium ion concentration |
| GO_0007612 | Biological process | learning |
| GO_0007611 | Biological process | learning or memory |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0098703 | Biological process | calcium ion import across plasma membrane |
| GO_0099608 | Biological process | regulation of action potential firing pattern |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0060291 | Biological process | long-term synaptic potentiation |
| GO_0098815 | Biological process | modulation of excitatory postsynaptic potential |
| GO_0070050 | Biological process | neuron cellular homeostasis |
| GO_0007154 | Biological process | cell communication |
| GO_0007613 | Biological process | memory |
| GO_0050890 | Biological process | cognition |
| GO_1903779 | Biological process | regulation of cardiac conduction |
| GO_1990034 | Biological process | calcium ion export across plasma membrane |
| GO_0050808 | Biological process | synapse organization |
| GO_0106056 | Biological process | regulation of calcineurin-mediated signaling |
| GO_0071902 | Biological process | positive regulation of protein serine/threonine kinase activity |
| GO_0048172 | Biological process | regulation of short-term neuronal synaptic plasticity |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0098793 | Cellular component | presynapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0043204 | Cellular component | perikaryon |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0043679 | Cellular component | axon terminus |
| GO_0098794 | Cellular component | postsynapse |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0030425 | Cellular component | dendrite |
| GO_0045202 | Cellular component | synapse |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0030424 | Cellular component | axon |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_1905060 | Molecular function | calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration |
| GO_0015085 | Molecular function | calcium ion transmembrane transporter activity |
| GO_0015081 | Molecular function | sodium ion transmembrane transporter activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005432 | Molecular function | calcium:sodium antiporter activity |
| GO_0005516 | Molecular function | calmodulin binding |
| Gene name | SLC8A2 |
| Protein name | Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) Solute carrier family 8 member A2 |
| Synonyms | NCX2 KIAA1087 |
| Description | FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion. . |
| Accessions | F5H6L7 Q9UPR5 M0R1Z4 M0R211 ENST00000236877.11 ENST00000597014.1 ENST00000542837.2 ENST00000594353.1 |
