HTR2B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HTR2B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR2B at tissue level.

III. Associated gene sets

GO_0019934Biological processcGMP-mediated signaling
GO_0051781Biological processpositive regulation of cell division
GO_0071502Biological processcellular response to temperature stimulus
GO_0019722Biological processcalcium-mediated signaling
GO_0001755Biological processneural crest cell migration
GO_0050795Biological processregulation of behavior
GO_0003300Biological processcardiac muscle hypertrophy
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0007210Biological processserotonin receptor signaling pathway
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0098664Biological processG protein-coupled serotonin receptor signaling pathway
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0010513Biological processpositive regulation of phosphatidylinositol biosynthetic process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0070371Biological processERK1 and ERK2 cascade
GO_0007208Biological processphospholipase C-activating serotonin receptor signaling pathway
GO_0048598Biological processembryonic morphogenesis
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0007268Biological processchemical synaptic transmission
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0002031Biological processG protein-coupled receptor internalization
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0014033Biological processneural crest cell differentiation
GO_0070528Biological processprotein kinase C signaling
GO_0016310Biological processphosphorylation
GO_0014827Biological processintestine smooth muscle contraction
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0001819Biological processpositive regulation of cytokine production
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0042310Biological processvasoconstriction
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0003007Biological processheart morphogenesis
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0098666Cellular componentG protein-coupled serotonin receptor complex
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005096Molecular functionGTPase activator activity
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0051378Molecular functionserotonin binding
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0001587Molecular functionGq/11-coupled serotonin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTR2B
Protein name5-hydroxytryptamine receptor 2B (Serotonin receptor 2B)
5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)
Synonyms
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors . Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways . Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores . Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior . Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). .

AccessionsB3VRD0
B3VRD5
P41595
Q7Z580
B3VRC5
ENST00000258400.4