HTR1A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HTR1A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR1A at tissue level.

III. Associated gene sets

GO_0046883Biological processregulation of hormone secretion
GO_0035640Biological processexploration behavior
GO_0019229Biological processregulation of vasoconstriction
GO_0042053Biological processregulation of dopamine metabolic process
GO_0050795Biological processregulation of behavior
GO_0007210Biological processserotonin receptor signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0001662Biological processbehavioral fear response
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0007198Biological processadenylate cyclase-inhibiting serotonin receptor signaling pathway
GO_0007214Biological processgamma-aminobutyric acid signaling pathway
GO_0014062Biological processregulation of serotonin secretion
GO_0042428Biological processserotonin metabolic process
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0090722Molecular functionreceptor-receptor interaction
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0051378Molecular functionserotonin binding
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTR1A
Protein name5-hydroxytryptamine receptor 1A (Serotonin receptor 1A)
5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (G-21) (Serotonin receptor 1A)
5-hydroxytryptamine receptor 1A
SynonymsADRB2RL1
5HT1A
hCG_16836
ADRBRL1
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. .

FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. .

AccessionsENST00000506598.1
ENST00000323865.5
Q5ZGX3
P08908
D6RA34