ALDH1A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030392Biological processfructosamine catabolic process
GO_0001523Biological processretinoid metabolic process
GO_0006081Biological processcellular aldehyde metabolic process
GO_0036438Biological processmaintenance of lens transparency
GO_0042572Biological processretinol metabolic process
GO_0110095Biological processcellular detoxification of aldehyde
GO_0009449Biological processgamma-aminobutyric acid biosynthetic process
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0043878Molecular functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
GO_0051287Molecular functionNAD binding
GO_0004029Molecular functionaldehyde dehydrogenase (NAD+) activity
GO_0001758Molecular functionretinal dehydrogenase activity
GO_0019145Molecular functionaminobutyraldehyde dehydrogenase (NAD+) activity
GO_0005096Molecular functionGTPase activator activity
GO_0005497Molecular functionandrogen binding
GO_0106373Molecular function3-deoxyglucosone dehydrogenase activity
GO_0018479Molecular functionbenzaldehyde dehydrogenase (NAD+) activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALDH1A1
Protein nameAldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1)
Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1)
SynonymsALDH1
PUMB1
ALDC
DescriptionFUNCTION: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid . Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification . Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins . Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). .

AccessionsENST00000446946.1
Q5SYQ9
Q5SYQ7
ENST00000376939.5
Q5SYQ8
P00352
ENST00000419959.5
ENST00000297785.8