Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 23 studies | 36% ± 15% | |
mast cell | 17 studies | 28% ± 9% | |
ciliated cell | 16 studies | 62% ± 20% | |
astrocyte | 15 studies | 38% ± 16% | |
macrophage | 12 studies | 23% ± 8% | |
epithelial cell | 12 studies | 40% ± 17% | |
basal cell | 11 studies | 47% ± 19% | |
endothelial cell of lymphatic vessel | 10 studies | 27% ± 10% | |
club cell | 9 studies | 56% ± 20% | |
goblet cell | 9 studies | 37% ± 11% | |
secretory cell | 8 studies | 49% ± 20% | |
epithelial cell of proximal tubule | 7 studies | 44% ± 10% | |
enterocyte | 7 studies | 30% ± 6% | |
endothelial cell | 7 studies | 24% ± 9% | |
alveolar macrophage | 6 studies | 27% ± 8% | |
respiratory goblet cell | 6 studies | 81% ± 11% | |
kidney loop of Henle epithelial cell | 6 studies | 41% ± 8% | |
smooth muscle cell | 6 studies | 45% ± 23% | |
glial cell | 6 studies | 63% ± 18% | |
renal alpha-intercalated cell | 5 studies | 68% ± 9% | |
enteroendocrine cell | 5 studies | 38% ± 14% | |
hematopoietic stem cell | 5 studies | 26% ± 7% | |
connective tissue cell | 5 studies | 40% ± 20% | |
hepatocyte | 5 studies | 67% ± 19% | |
type II pneumocyte | 4 studies | 22% ± 7% | |
deuterosomal cell | 4 studies | 65% ± 5% | |
duct epithelial cell | 4 studies | 52% ± 22% | |
ionocyte | 4 studies | 34% ± 6% | |
pancreatic A cell | 4 studies | 83% ± 12% | |
type B pancreatic cell | 4 studies | 41% ± 17% | |
intestinal crypt stem cell | 4 studies | 29% ± 7% | |
progenitor cell | 4 studies | 42% ± 15% | |
transit amplifying cell | 4 studies | 38% ± 26% | |
erythroblast | 4 studies | 42% ± 19% | |
Schwann cell | 4 studies | 59% ± 25% | |
adventitial cell | 4 studies | 31% ± 17% | |
mucus secreting cell | 4 studies | 50% ± 21% | |
acinar cell | 4 studies | 38% ± 16% | |
brush cell | 4 studies | 30% ± 5% | |
squamous epithelial cell | 3 studies | 53% ± 21% | |
myofibroblast cell | 3 studies | 59% ± 28% | |
serous secreting cell | 3 studies | 33% ± 16% | |
neuron | 3 studies | 40% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 99% | 23723.87 | 223 / 226 | 95% | 1053.67 | 387 / 406 |
kidney | 99% | 10968.38 | 88 / 89 | 95% | 703.69 | 855 / 901 |
pancreas | 100% | 15113.32 | 328 / 328 | 85% | 259.23 | 151 / 178 |
thymus | 100% | 14271.56 | 651 / 653 | 76% | 175.08 | 460 / 605 |
lung | 99% | 11107.10 | 572 / 578 | 63% | 241.16 | 726 / 1155 |
stomach | 99% | 27362.51 | 357 / 359 | 56% | 184.16 | 160 / 286 |
intestine | 100% | 17190.77 | 963 / 966 | 50% | 130.54 | 264 / 527 |
esophagus | 82% | 4496.67 | 1192 / 1445 | 61% | 201.97 | 111 / 183 |
prostate | 96% | 5858.23 | 236 / 245 | 44% | 111.83 | 223 / 502 |
adrenal gland | 99% | 12128.47 | 256 / 258 | 32% | 83.72 | 73 / 230 |
uterus | 98% | 9191.63 | 167 / 170 | 32% | 112.36 | 148 / 459 |
brain | 82% | 6299.34 | 2162 / 2642 | 32% | 36.27 | 223 / 705 |
breast | 96% | 6738.79 | 441 / 459 | 12% | 12.14 | 131 / 1118 |
ovary | 100% | 13783.67 | 180 / 180 | 7% | 9.45 | 30 / 430 |
adipose | 96% | 7810.51 | 1161 / 1204 | 0% | 0 | 0 / 0 |
bladder | 71% | 2530.67 | 15 / 21 | 24% | 72.91 | 122 / 504 |
spleen | 91% | 4074.37 | 219 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 88% | 6069.94 | 1170 / 1335 | 0% | 0 | 0 / 0 |
muscle | 64% | 2504.17 | 510 / 803 | 0% | 0 | 0 / 0 |
skin | 19% | 584.25 | 352 / 1809 | 36% | 91.85 | 168 / 472 |
heart | 45% | 1896.25 | 389 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 42% | 125.30 | 19 / 45 |
lymph node | 0% | 0 | 0 / 0 | 41% | 54.53 | 12 / 29 |
peripheral blood | 3% | 74.00 | 24 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 3.14 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0030392 | Biological process | fructosamine catabolic process |
GO_0001523 | Biological process | retinoid metabolic process |
GO_0006081 | Biological process | cellular aldehyde metabolic process |
GO_0036438 | Biological process | maintenance of lens transparency |
GO_0042572 | Biological process | retinol metabolic process |
GO_0110095 | Biological process | cellular detoxification of aldehyde |
GO_0009449 | Biological process | gamma-aminobutyric acid biosynthetic process |
GO_0120163 | Biological process | negative regulation of cold-induced thermogenesis |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0043878 | Molecular function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
GO_0051287 | Molecular function | NAD binding |
GO_0004029 | Molecular function | aldehyde dehydrogenase (NAD+) activity |
GO_0001758 | Molecular function | retinal dehydrogenase activity |
GO_0019145 | Molecular function | aminobutyraldehyde dehydrogenase (NAD+) activity |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005497 | Molecular function | androgen binding |
GO_0106373 | Molecular function | 3-deoxyglucosone dehydrogenase activity |
GO_0018479 | Molecular function | benzaldehyde dehydrogenase (NAD+) activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ALDH1A1 |
Protein name | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) |
Synonyms | ALDH1 PUMB1 ALDC |
Description | FUNCTION: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid . Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification . Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins . Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). . |
Accessions | ENST00000446946.1 Q5SYQ9 Q5SYQ7 ENST00000376939.5 Q5SYQ8 P00352 ENST00000419959.5 ENST00000297785.8 |