RPS6KA4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RPS6KA4 at tissue level.

III. Associated gene sets

GO_0032793Biological processpositive regulation of CREB transcription factor activity
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0006954Biological processinflammatory response
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0043687Biological processpost-translational protein modification
GO_0006338Biological processchromatin remodeling
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0035556Biological processintracellular signal transduction
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001818Biological processnegative regulation of cytokine production
GO_0006468Biological processprotein phosphorylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0044022Molecular functionhistone H3S28 kinase activity
GO_0004711Molecular functionribosomal protein S6 kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0035175Molecular functionhistone H3S10 kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPS6KA4
Protein nameRibosomal protein S6 kinase (EC 2.7.11.1)
RPS6KA4 protein
Ribosomal protein S6 kinase A4
Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
SynonymsMSK2
DescriptionFUNCTION: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. .

AccessionsE9PKU3
A0PJF8
ENST00000528057.5
A0A0A6YYC0
E9PJN1
ENST00000334205.9 [O75676-1]
ENST00000530504.1
O75676
ENST00000528355.5