FAM107A | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	36% ± 13%	Explore
astrocyte	14 studies	41% ± 14%	Explore
endothelial cell of artery	13 studies	46% ± 24%	Explore
capillary endothelial cell	11 studies	39% ± 14%	Explore
retinal cone cell	7 studies	38% ± 19%	Explore
retinal rod cell	7 studies	27% ± 7%	Explore
vein endothelial cell	7 studies	36% ± 19%	Explore
endothelial cell of vascular tree	7 studies	39% ± 15%	Explore
secretory cell	5 studies	29% ± 8%	Explore
retinal pigment epithelial cell	4 studies	27% ± 13%	Explore
glomerular endothelial cell	3 studies	24% ± 2%	Explore
pericyte	3 studies	23% ± 7%	Explore

Name	Number of supported studies	Average coverage
eye	5 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	84933.69	2642 / 2642	100%	697.29	702 / 705
thymus	70%	7515.56	457 / 653	91%	79.56	550 / 605
prostate	83%	12841.23	203 / 245	75%	23.55	378 / 502
lung	80%	14409.03	464 / 578	16%	3.53	181 / 1155
kidney	42%	3696.58	37 / 89	48%	14.14	428 / 901
breast	70%	8456.80	321 / 459	14%	4.61	156 / 1118
ovary	4%	284.83	7 / 180	77%	55.76	330 / 430
bladder	67%	10710.86	14 / 21	5%	1.13	25 / 504
adipose	72%	9493.69	861 / 1204	0%	0	0 / 0
uterus	52%	4809.56	89 / 170	16%	8.76	75 / 459
heart	61%	7363.87	525 / 861	0%	0	0 / 0
esophagus	38%	3885.44	554 / 1445	7%	1.29	13 / 183
intestine	39%	3973.33	381 / 966	3%	0.61	17 / 527
stomach	30%	2960.74	109 / 359	6%	1.03	16 / 286
adrenal gland	1%	154.12	3 / 258	30%	6.89	68 / 230
pancreas	0%	0	0 / 328	26%	5.15	46 / 178
skin	12%	996.59	219 / 1809	3%	2.81	12 / 472
spleen	14%	1038.52	34 / 241	0%	0	0 / 0
blood vessel	10%	924.57	136 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	9%	1.93	4 / 45
eye	0%	0	0 / 0	6%	2.21	5 / 80
liver	0%	0	0 / 226	5%	0.87	22 / 406
muscle	3%	217.52	25 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0001558	Biological process	regulation of cell growth
GO_0030041	Biological process	actin filament polymerization
GO_0051895	Biological process	negative regulation of focal adhesion assembly
GO_0051017	Biological process	actin filament bundle assembly
GO_0031669	Biological process	cellular response to nutrient levels
GO_0030335	Biological process	positive regulation of cell migration
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_1900272	Biological process	negative regulation of long-term synaptic potentiation
GO_0050890	Biological process	cognition
GO_0031398	Biological process	positive regulation of protein ubiquitination
GO_0071385	Biological process	cellular response to glucocorticoid stimulus
GO_0070507	Biological process	regulation of microtubule cytoskeleton organization
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0031647	Biological process	regulation of protein stability
GO_0032587	Cellular component	ruffle membrane
GO_0016607	Cellular component	nuclear speck
GO_0043005	Cellular component	neuron projection
GO_0005925	Cellular component	focal adhesion
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0003674	Molecular function	molecular_function

Gene name	FAM107A
Protein name	Actin-associated protein FAM107A Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)
Synonyms	TU3A hCG_22019 DRR1
Description	FUNCTION: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner . Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner . May play a role in tumor development . .
Accessions	ENST00000394481.5 [O95990-1] Q6IAM1 C9JAU5 ENST00000465970.1 ENST00000447756.2 [O95990-3] ENST00000360997.7 [O95990-1] ENST00000649301.1 [O95990-1] ENST00000474531.5 [O95990-4] O95990 ENST00000464064.5 [O95990-2]

FAM107A report