LYNX1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LYNX1 at tissue level.

III. Associated gene sets

GO_0099601Biological processregulation of neurotransmitter receptor activity
GO_0007271Biological processsynaptic transmission, cholinergic
GO_0098552Cellular componentside of membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0030548Molecular functionacetylcholine receptor regulator activity
GO_0033130Molecular functionacetylcholine receptor binding
GO_0008200Molecular functionion channel inhibitor activity
GO_0030550Molecular functionacetylcholine receptor inhibitor activity

IV. Literature review

[source]
Gene nameLYNX1
Protein nameLy-6/neurotoxin-like protein 1 (Endogenous prototoxin LYNX1) (Testicular tissue protein Li 112)
Ly6/neurotoxin 1
Alternative protein LYNX1
Synonyms
DescriptionFUNCTION: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) . The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs . Prevents plasticity in the primary visual cortex late in life (By similarity). .

AccessionsENST00000613110.4
ENST00000614268.4
ENST00000620006.4 [P0DP58-1]
A0A087WZS0
L8EB58
P0DP58
ENST00000652477.1 [P0DP58-1]
A0A087WYG6
ENST00000621401.4 [P0DP58-1]
ENST00000614491.1 [P0DP58-1]