NDE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007059Biological processchromosome segregation
GO_0051298Biological processcentrosome duplication
GO_0051642Biological processcentrosome localization
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051301Biological processcell division
GO_0001764Biological processneuron migration
GO_0007020Biological processmicrotubule nucleation
GO_0007100Biological processmitotic centrosome separation
GO_0051303Biological processestablishment of chromosome localization
GO_0021987Biological processcerebral cortex development
GO_0016477Biological processcell migration
GO_0047496Biological processvesicle transport along microtubule
GO_0007405Biological processneuroblast proliferation
GO_0005874Cellular componentmicrotubule
GO_0016020Cellular componentmembrane
GO_0031616Cellular componentspindle pole centrosome
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005871Cellular componentkinesin complex
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0032154Cellular componentcleavage furrow
GO_0042802Molecular functionidentical protein binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDE1
Protein nameNudE neurodevelopment protein 1 (NudE nuclear distribution gene E homolog 1 (A. nidulans), isoform CRA_c)
Nuclear distribution protein nudE homolog 1
NudE neurodevelopment protein 1
Alternative protein NDE1
Nuclear distribution protein nudE homolog 1 (NudE neurodevelopment protein 1)
Epididymis secretory sperm binding protein (NudE neurodevelopment protein 1 isoform B) (NudE nuclear distribution gene E homolog 1 (A. nidulans), isoform CRA_b)
NudE neurodevelopment protein 1 isoform A
NudE neurodevelopment protein 1 isoform C
Nuclear distribution protein nudE homolog 1 (NudE)
SynonymsNUDE
hCG_38895
DescriptionFUNCTION: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. .

AccessionsENST00000674538.1
ENST00000396354.6 [Q9NXR1-2]
ENST00000396355.5 [Q9NXR1-2]
ENST00000674581.1
I3L522
A0A0J9YYF5
X5DP35
ENST00000674995.1
ENST00000632288.1
ENST00000631844.1 [Q9NXR1-2]
ENST00000577101.6
ENST00000632578.1
ENST00000674900.1
ENST00000570727.5
A0A6Q8PHH1
I3L2S8
ENST00000633132.1
ENST00000574109.5
I3L2T8
ENST00000576502.5
ENST00000674888.1 [Q9NXR1-2]
A0A6Q8PEY3
ENST00000572756.6
A0A6Q8PG46
L8E8T4
I3L2R3
A0A0J9YY14
ENST00000572967.1
ENST00000573203.5
X5DRF9
Q9NXR1
I3L533
ENST00000634195.1
X5DR54
ENST00000674588.1
A0A6Q8PGV6
I3L464
ENST00000632452.1
ENST00000631789.1
ENST00000632668.1
ENST00000674554.1 [Q9NXR1-2]
ENST00000675171.1
I3L2R9
ENST00000631507.1
ENST00000573694.5
ENST00000675951.1 [Q9NXR1-2]
ENST00000631923.1 [Q9NXR1-2]
I3L3G9
ENST00000675926.1 [Q9NXR1-2]