PLAA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903423Biological processpositive regulation of synaptic vesicle recycling
GO_0006954Biological processinflammatory response
GO_1900045Biological processnegative regulation of protein K63-linked ubiquitination
GO_2001224Biological processpositive regulation of neuron migration
GO_0007165Biological processsignal transduction
GO_0016236Biological processmacroautophagy
GO_1903861Biological processpositive regulation of dendrite extension
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0010992Biological processubiquitin recycling
GO_0032430Biological processpositive regulation of phospholipase A2 activity
GO_0006693Biological processprostaglandin metabolic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006644Biological processphospholipid metabolic process
GO_0007399Biological processnervous system development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0070062Cellular componentextracellular exosome
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016005Molecular functionphospholipase A2 activator activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene namePLAA
Protein namePhospholipase A2 activating protein
Phospholipase A-2-activating protein (PLA2P) (PLAP)
SynonymsPLAP
DescriptionFUNCTION: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP . Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes . Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis . .

AccessionsENST00000487173.5
H0YC16
H0YBW4
ENST00000517642.5
ENST00000520884.5
H0YAU9
Q9Y263
ENST00000523212.1
ENST00000397292.8
E5RIM3