PPP2CA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	25 studies	24% ± 7%	Explore
natural killer cell	25 studies	25% ± 7%	Explore
endothelial cell	20 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	19 studies	24% ± 7%	Explore
T cell	18 studies	24% ± 6%	Explore
classical monocyte	17 studies	25% ± 10%	Explore
fibroblast	17 studies	24% ± 7%	Explore
macrophage	16 studies	24% ± 9%	Explore
pericyte	16 studies	24% ± 7%	Explore
smooth muscle cell	16 studies	23% ± 5%	Explore
regulatory T cell	16 studies	24% ± 5%	Explore
conventional dendritic cell	13 studies	27% ± 15%	Explore
non-classical monocyte	12 studies	27% ± 12%	Explore
monocyte	11 studies	22% ± 6%	Explore
naive B cell	11 studies	23% ± 6%	Explore
connective tissue cell	11 studies	23% ± 8%	Explore
memory B cell	11 studies	24% ± 5%	Explore
epithelial cell	11 studies	34% ± 21%	Explore
basal cell	11 studies	29% ± 11%	Explore
mature NK T cell	10 studies	22% ± 3%	Explore
gamma-delta T cell	10 studies	29% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	28% ± 5%	Explore
plasmacytoid dendritic cell	9 studies	25% ± 8%	Explore
endothelial cell of vascular tree	9 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 6%	Explore
ciliated cell	8 studies	31% ± 15%	Explore
dendritic cell	7 studies	34% ± 20%	Explore
mucosal invariant T cell	7 studies	28% ± 8%	Explore
myeloid cell	7 studies	29% ± 13%	Explore
oligodendrocyte precursor cell	7 studies	29% ± 14%	Explore
mast cell	6 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	24% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
leukocyte	6 studies	25% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
glutamatergic neuron	6 studies	36% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	26% ± 8%	Explore
precursor B cell	6 studies	31% ± 10%	Explore
innate lymphoid cell	6 studies	28% ± 7%	Explore
astrocyte	6 studies	24% ± 6%	Explore
microglial cell	6 studies	22% ± 6%	Explore
secretory cell	6 studies	24% ± 7%	Explore
T follicular helper cell	6 studies	24% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	30% ± 9%	Explore
hematopoietic precursor cell	5 studies	27% ± 12%	Explore
plasma cell	5 studies	25% ± 13%	Explore
plasmablast	5 studies	43% ± 18%	Explore
mononuclear phagocyte	5 studies	27% ± 11%	Explore
kidney loop of Henle epithelial cell	5 studies	17% ± 1%	Explore
myofibroblast cell	5 studies	29% ± 9%	Explore
endothelial cell of artery	5 studies	19% ± 4%	Explore
vein endothelial cell	5 studies	18% ± 3%	Explore
abnormal cell	5 studies	26% ± 14%	Explore
pro-B cell	5 studies	30% ± 3%	Explore
neuron	5 studies	32% ± 18%	Explore
oligodendrocyte	5 studies	20% ± 5%	Explore
exhausted T cell	4 studies	27% ± 8%	Explore
retinal ganglion cell	4 studies	59% ± 30%	Explore
erythroblast	4 studies	31% ± 19%	Explore
hematopoietic stem cell	4 studies	21% ± 4%	Explore
capillary endothelial cell	4 studies	21% ± 3%	Explore
immature B cell	4 studies	26% ± 6%	Explore
retina horizontal cell	4 studies	28% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 8%	Explore
endothelial cell of lymphatic vessel	4 studies	22% ± 6%	Explore
type I pneumocyte	3 studies	27% ± 8%	Explore
squamous epithelial cell	3 studies	42% ± 22%	Explore
pancreatic A cell	3 studies	49% ± 11%	Explore
type B pancreatic cell	3 studies	50% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	26% ± 7%	Explore
placental villous trophoblast	3 studies	26% ± 8%	Explore
lymphocyte	3 studies	30% ± 10%	Explore
tissue-resident macrophage	3 studies	20% ± 3%	Explore
Mueller cell	3 studies	20% ± 4%	Explore
rod bipolar cell	3 studies	19% ± 4%	Explore
germinal center B cell	3 studies	37% ± 8%	Explore
granulocyte	3 studies	19% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 6%	Explore
GABAergic neuron	3 studies	42% ± 4%	Explore
pancreatic ductal cell	3 studies	57% ± 26%	Explore
enteroendocrine cell	3 studies	30% ± 17%	Explore
goblet cell	3 studies	27% ± 9%	Explore
intestinal crypt stem cell	3 studies	20% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 12%	Explore
T-helper 17 cell	3 studies	22% ± 4%	Explore
interneuron	3 studies	37% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	25% ± 8%	Explore
lung	9 studies	27% ± 8%	Explore
brain	8 studies	31% ± 14%	Explore
kidney	5 studies	20% ± 4%	Explore
intestine	5 studies	24% ± 12%	Explore
eye	5 studies	24% ± 8%	Explore
uterus	5 studies	24% ± 10%	Explore
lymph node	4 studies	19% ± 3%	Explore
pancreas	3 studies	50% ± 14%	Explore
bone marrow	3 studies	22% ± 5%	Explore
prostate	3 studies	23% ± 6%	Explore
breast	3 studies	24% ± 7%	Explore
placenta	3 studies	24% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	7403.83	258 / 258	100%	80.52	230 / 230
bladder	100%	5633.76	21 / 21	100%	69.93	504 / 504
breast	100%	5973.07	459 / 459	100%	96.05	1118 / 1118
esophagus	100%	6663.15	1445 / 1445	100%	71.12	183 / 183
kidney	100%	5215.47	89 / 89	100%	65.19	901 / 901
liver	100%	3578.33	226 / 226	100%	46.50	406 / 406
prostate	100%	5164.28	245 / 245	100%	74.44	502 / 502
stomach	100%	4613.81	359 / 359	100%	59.23	286 / 286
thymus	100%	5900.18	653 / 653	100%	82.03	605 / 605
uterus	100%	6435.90	170 / 170	100%	88.49	459 / 459
brain	100%	9460.12	2640 / 2642	100%	98.01	705 / 705
intestine	100%	5892.41	966 / 966	100%	66.38	526 / 527
skin	100%	8486.49	1809 / 1809	100%	62.65	471 / 472
lung	100%	6286.84	576 / 578	100%	66.46	1155 / 1155
ovary	100%	4838.78	180 / 180	100%	58.17	428 / 430
pancreas	99%	2933.33	324 / 328	100%	64.08	178 / 178
adipose	100%	6129.40	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	94.97	29 / 29
muscle	100%	6594.13	803 / 803	0%	0	0 / 0
spleen	100%	5532.84	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	80.24	45 / 45
ureter	0%	0	0 / 0	100%	31.47	1 / 1
blood vessel	100%	5970.12	1334 / 1335	0%	0	0 / 0
peripheral blood	98%	6054.45	912 / 929	0%	0	0 / 0
heart	98%	6148.54	843 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	38.46	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043029	Biological process	T cell homeostasis
GO_0007498	Biological process	mesoderm development
GO_1904539	Biological process	negative regulation of glycolytic process through fructose-6-phosphate
GO_0006470	Biological process	protein dephosphorylation
GO_0000278	Biological process	mitotic cell cycle
GO_1904526	Biological process	regulation of microtubule binding
GO_0010288	Biological process	response to lead ion
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0035970	Biological process	peptidyl-threonine dephosphorylation
GO_0001932	Biological process	regulation of protein phosphorylation
GO_1904528	Biological process	positive regulation of microtubule binding
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0035331	Biological process	negative regulation of hippo signaling
GO_1900227	Biological process	positive regulation of NLRP3 inflammasome complex assembly
GO_0051321	Biological process	meiotic cell cycle
GO_0035556	Biological process	intracellular signal transduction
GO_0010719	Biological process	negative regulation of epithelial to mesenchymal transition
GO_0070262	Biological process	peptidyl-serine dephosphorylation
GO_0045595	Biological process	regulation of cell differentiation
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0040008	Biological process	regulation of growth
GO_0000775	Cellular component	chromosome, centromeric region
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0000922	Cellular component	spindle pole
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0090443	Cellular component	FAR/SIN/STRIPAK complex
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0008287	Cellular component	protein serine/threonine phosphatase complex
GO_0000159	Cellular component	protein phosphatase type 2A complex
GO_0005634	Cellular component	nucleus
GO_0004721	Molecular function	phosphoprotein phosphatase activity
GO_0017018	Molecular function	myosin phosphatase activity
GO_0050811	Molecular function	GABA receptor binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity
GO_0046872	Molecular function	metal ion binding
GO_0048156	Molecular function	tau protein binding
GO_0004722	Molecular function	protein serine/threonine phosphatase activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPP2CA
Protein name	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms	hCG_16586
Description	FUNCTION: PP2A is the major phosphatase for microtubule-associated proteins (MAPs) . PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase . Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53 . Activates RAF1 by dephosphorylating it at 'Ser-259' . Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint . Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC . Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 . Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome (By similarity). .
Accessions	ENST00000703310.1 E7ESG8 A0A8V8TRB3 A0A8V8TQA1 ENST00000703308.1 ENST00000703354.1 ENST00000703311.1 ENST00000522385.2 B3KUN1 ENST00000523082.1 A0A8V8TQU8 A0A8V8TRA6 P67775 B3KQ51 ENST00000703309.1 ENST00000481195.6 [P67775-1] Q6I9T8

PPP2CA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review