GLRA1 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GLRA1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	85%	8.03	278 / 328	8%	0.27	15 / 178
brain	81%	20.68	2148 / 2642	8%	0.18	53 / 705
adrenal gland	53%	5.44	137 / 258	26%	0.83	59 / 230
muscle	50%	1.69	400 / 803	0%	0	0 / 0
thymus	40%	1.37	264 / 653	4%	0.10	22 / 605
lung	39%	1.28	226 / 578	0%	0.01	4 / 1155
adipose	37%	1.27	445 / 1204	0%	0	0 / 0
breast	36%	1.27	165 / 459	1%	0.02	8 / 1118
bladder	33%	0.86	7 / 21	1%	0.01	3 / 504
uterus	34%	0.95	57 / 170	0%	0	0 / 459
esophagus	33%	1.00	475 / 1445	1%	0.01	1 / 183
intestine	33%	1.04	317 / 966	0%	0.01	2 / 527
spleen	33%	1.03	80 / 241	0%	0	0 / 0
kidney	31%	0.97	28 / 89	1%	0.02	5 / 901
prostate	31%	0.87	76 / 245	0%	0.00	2 / 502
ovary	31%	0.84	55 / 180	0%	0.00	1 / 430
stomach	29%	0.87	105 / 359	1%	0.02	3 / 286
blood vessel	30%	0.92	395 / 1335	0%	0	0 / 0
heart	28%	0.85	243 / 861	0%	0	0 / 0
skin	27%	0.85	485 / 1809	0%	0	0 / 472
liver	20%	0.62	46 / 226	0%	0.01	1 / 406
peripheral blood	17%	0.53	159 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007601	Biological process	visual perception
GO_0007628	Biological process	adult walking behavior
GO_0002087	Biological process	regulation of respiratory gaseous exchange by nervous system process
GO_0007218	Biological process	neuropeptide signaling pathway
GO_0042391	Biological process	regulation of membrane potential
GO_0006821	Biological process	chloride transport
GO_2000344	Biological process	positive regulation of acrosome reaction
GO_0071361	Biological process	cellular response to ethanol
GO_0097305	Biological process	response to alcohol
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0071294	Biological process	cellular response to zinc ion
GO_0006811	Biological process	monoatomic ion transport
GO_0006936	Biological process	muscle contraction
GO_0060013	Biological process	righting reflex
GO_0051970	Biological process	negative regulation of transmission of nerve impulse
GO_0050884	Biological process	neuromuscular process controlling posture
GO_0099505	Biological process	regulation of presynaptic membrane potential
GO_0007340	Biological process	acrosome reaction
GO_0060012	Biological process	synaptic transmission, glycinergic
GO_1902476	Biological process	chloride transmembrane transport
GO_0007268	Biological process	chemical synaptic transmission
GO_0019228	Biological process	neuronal action potential
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0001964	Biological process	startle response
GO_0060080	Biological process	inhibitory postsynaptic potential
GO_0009897	Cellular component	external side of plasma membrane
GO_0098690	Cellular component	glycinergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043204	Cellular component	perikaryon
GO_1902495	Cellular component	transmembrane transporter complex
GO_0060077	Cellular component	inhibitory synapse
GO_0043025	Cellular component	neuronal cell body
GO_0043005	Cellular component	neuron projection
GO_0030425	Cellular component	dendrite
GO_0034707	Cellular component	chloride channel complex
GO_0045202	Cellular component	synapse
GO_0045211	Cellular component	postsynaptic membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0005231	Molecular function	excitatory extracellular ligand-gated monoatomic ion channel activity
GO_0016934	Molecular function	extracellularly glycine-gated chloride channel activity
GO_0030594	Molecular function	neurotransmitter receptor activity
GO_0008270	Molecular function	zinc ion binding
GO_0016594	Molecular function	glycine binding
GO_0030977	Molecular function	taurine binding
GO_0099507	Molecular function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005515	Molecular function	protein binding
GO_0005254	Molecular function	chloride channel activity

IV. Literature review

[source]

Gene name	GLRA1
Protein name	Glycine receptor alpha 1 GLRA1 protein Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
Synonyms
Description	FUNCTION: Glycine receptors are ligand-gated chloride channels . Channel opening is triggered by extracellular glycine . Channel opening is also triggered by taurine and beta-alanine . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . Channel activity is potentiated by ethanol . Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). .
Accessions	E5RJ70 Q14C71 ENST00000462581.6 ENST00000274576.9 [P23415-2] ENST00000455880.2 [P23415-1] P23415

GLRA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review