EIF2S1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990737Biological processresponse to manganese-induced endoplasmic reticulum stress
GO_0034063Biological processstress granule assembly
GO_0034605Biological processcellular response to heat
GO_1904373Biological processresponse to kainic acid
GO_0034644Biological processcellular response to UV
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0036490Biological processregulation of translation in response to endoplasmic reticulum stress
GO_0140468Biological processHRI-mediated signaling
GO_0006413Biological processtranslational initiation
GO_0036499Biological processPERK-mediated unfolded protein response
GO_0034599Biological processcellular response to oxidative stress
GO_0034198Biological processcellular response to amino acid starvation
GO_0043558Biological processregulation of translational initiation in response to stress
GO_0000423Biological processmitophagy
GO_2000676Biological processpositive regulation of type B pancreatic cell apoptotic process
GO_0032057Biological processnegative regulation of translational initiation in response to stress
GO_0005850Cellular componenteukaryotic translation initiation factor 2 complex
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0097451Cellular componentglial limiting end-foot
GO_0033290Cellular componenteukaryotic 48S preinitiation complex
GO_0044207Cellular componenttranslation initiation ternary complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0003743Molecular functiontranslation initiation factor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF2S1
Protein nameEukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha)
SynonymshCG_21909
EIF2A
DescriptionFUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA . This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC) . Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex . In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B . EIF2S1/ component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming . .

AccessionsG3V4T5
H0YJS4
P05198
ENST00000557310.5
ENST00000256383.11
ENST00000466499.6
Q53XC0
ENST00000555876.1