STX4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	21 studies	22% ± 6%	Explore
natural killer cell	7 studies	17% ± 1%	Explore
conventional dendritic cell	7 studies	25% ± 10%	Explore
monocyte	6 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	17% ± 2%	Explore
epithelial cell	6 studies	28% ± 11%	Explore
classical monocyte	5 studies	23% ± 6%	Explore
myeloid cell	5 studies	30% ± 5%	Explore
endothelial cell	5 studies	24% ± 5%	Explore
fibroblast	4 studies	23% ± 7%	Explore
non-classical monocyte	3 studies	22% ± 3%	Explore
dendritic cell	3 studies	31% ± 5%	Explore
endothelial cell of vascular tree	3 studies	18% ± 1%	Explore
alveolar macrophage	3 studies	20% ± 4%	Explore
oligodendrocyte	3 studies	23% ± 5%	Explore
mononuclear phagocyte	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	3 studies	18% ± 2%	Explore
lung	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4273.00	258 / 258	100%	29.84	230 / 230
esophagus	100%	2936.23	1445 / 1445	100%	23.88	183 / 183
liver	100%	2193.20	226 / 226	100%	32.11	406 / 406
ovary	100%	3157.87	180 / 180	100%	23.02	430 / 430
skin	100%	3794.28	1809 / 1809	100%	36.52	472 / 472
thymus	100%	3374.96	653 / 653	100%	42.41	605 / 605
uterus	100%	3268.05	170 / 170	100%	45.23	459 / 459
lung	100%	4555.24	578 / 578	100%	36.77	1154 / 1155
brain	100%	2097.19	2634 / 2642	100%	37.76	705 / 705
pancreas	100%	1552.87	327 / 328	100%	49.32	178 / 178
kidney	100%	2874.42	89 / 89	100%	45.41	898 / 901
stomach	100%	2368.28	359 / 359	100%	33.55	285 / 286
intestine	100%	3404.44	966 / 966	100%	38.29	525 / 527
bladder	100%	3369.24	21 / 21	100%	43.06	502 / 504
prostate	100%	3352.78	245 / 245	99%	32.63	499 / 502
breast	100%	3711.13	459 / 459	99%	40.34	1105 / 1118
adipose	100%	4174.69	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	23.92	80 / 80
lymph node	0%	0	0 / 0	100%	56.76	29 / 29
spleen	100%	5290.83	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.21	45 / 45
ureter	0%	0	0 / 0	100%	24.30	1 / 1
muscle	100%	2234.61	802 / 803	0%	0	0 / 0
blood vessel	100%	2621.83	1333 / 1335	0%	0	0 / 0
heart	100%	2120.37	859 / 861	0%	0	0 / 0
peripheral blood	99%	3287.07	923 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002639	Biological process	positive regulation of immunoglobulin production
GO_0050921	Biological process	positive regulation of chemotaxis
GO_0006886	Biological process	intracellular protein transport
GO_0017157	Biological process	regulation of exocytosis
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0043311	Biological process	positive regulation of eosinophil degranulation
GO_0034394	Biological process	protein localization to cell surface
GO_0060291	Biological process	long-term synaptic potentiation
GO_2000010	Biological process	positive regulation of protein localization to cell surface
GO_0043085	Biological process	positive regulation of catalytic activity
GO_0035493	Biological process	SNARE complex assembly
GO_0035774	Biological process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0034599	Biological process	cellular response to oxidative stress
GO_0006887	Biological process	exocytosis
GO_0030335	Biological process	positive regulation of cell migration
GO_1903575	Biological process	cornified envelope assembly
GO_0048278	Biological process	vesicle docking
GO_0006836	Biological process	neurotransmitter transport
GO_0048284	Biological process	organelle fusion
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0006906	Biological process	vesicle fusion
GO_1902041	Biological process	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0071346	Biological process	cellular response to type II interferon
GO_0098978	Cellular component	glutamatergic synapse
GO_0005615	Cellular component	extracellular space
GO_0043219	Cellular component	lateral loop
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0000322	Cellular component	storage vacuole
GO_0012505	Cellular component	endomembrane system
GO_0016020	Cellular component	membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0036477	Cellular component	somatodendritic compartment
GO_0005773	Cellular component	vacuole
GO_0070062	Cellular component	extracellular exosome
GO_0098794	Cellular component	postsynapse
GO_0042581	Cellular component	specific granule
GO_0005802	Cellular component	trans-Golgi network
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0032589	Cellular component	neuron projection membrane
GO_0005768	Cellular component	endosome
GO_0030027	Cellular component	lamellipodium
GO_0031201	Cellular component	SNARE complex
GO_0016323	Cellular component	basolateral plasma membrane
GO_0035749	Cellular component	myelin sheath adaxonal region
GO_0016230	Molecular function	sphingomyelin phosphodiesterase activator activity
GO_0000149	Molecular function	SNARE binding
GO_0005484	Molecular function	SNAP receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	STX4
Protein name	Syntaxin 4 Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
Synonyms	STX4A
Description	FUNCTION: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). .
Accessions	ENST00000613541.1 H3BMK2 ENST00000460668.5 ENST00000496977.5 C9JFM5 ENST00000457779.6 A0A087WWW0 Q12846 ENST00000313843.8 [Q12846-1] ENST00000394998.5 [Q12846-2]

STX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review