TSC22D4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070050Biological processneuron cellular homeostasis
GO_1990138Biological processneuron projection extension
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006970Biological processresponse to osmotic stress
GO_0042593Biological processglucose homeostasis
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTSC22D4
Protein nameTSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)
TSC22D4 protein
TSC22 domain family member 4
SynonymsTHG1
THG1-PIT
DescriptionFUNCTION: Binds DNA and acts as a transcriptional repressor . Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release . May play a role in neurite elongation and survival (By similarity). .

AccessionsENST00000423266.5
ENST00000393991.5 [Q9Y3Q8-2]
H7BZ77
Q9Y3Q8
H7C0M8
ENST00000456330.1
ENST00000300181.7 [Q9Y3Q8-1]
Q8IV54