C4A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of C4A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of C4A at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0006958Biological processcomplement activation, classical pathway
GO_0006956Biological processcomplement activation
GO_2000427Biological processpositive regulation of apoptotic cell clearance
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0072562Cellular componentblood microparticle
GO_0030424Cellular componentaxon
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0070062Cellular componentextracellular exosome
GO_0045202Cellular componentsynapse
GO_0005576Cellular componentextracellular region
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0001849Molecular functioncomplement component C1q complex binding

IV. Literature review

[source]
Gene nameC4A
Protein nameC4A2 (C4A3) (C4A4) (C4A6) (C4B1)
Complement C4A (Rodgers blood group)
Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]
Complement C4A3
Complement C4-A
MHC class III region complement
SynonymsCPAMD2
CO4
DescriptionFUNCTION: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; FUNCTION: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

AccessionsA0A140TA32
A0A0G2JPR0
ENST00000549812.2
ENST00000698442.1
Q6U2K2
ENST00000375295.8
A0A8V8TLP6
Q30211
A0A140TA44
P0C0L4
ENST00000428956.7 [P0C0L4-1]
V9H0D6
ENST00000546746.5
ENST00000550297.2
ENST00000421274.6
A0A140TA49
ENST00000498271.1 [P0C0L4-2]
ENST00000383325.8