Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 11 studies | 56% ± 26% | |
| GABAergic neuron | 8 studies | 52% ± 24% | |
| interneuron | 5 studies | 53% ± 25% | |
| neuron | 4 studies | 32% ± 15% | |
| retinal bipolar neuron | 4 studies | 30% ± 11% | |
| OFF-bipolar cell | 4 studies | 32% ± 11% | |
| retinal ganglion cell | 4 studies | 41% ± 22% | |
| endothelial cell | 3 studies | 37% ± 9% | |
| rod bipolar cell | 3 studies | 27% ± 3% | |
| granule cell | 3 studies | 40% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 11 studies | 37% ± 26% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 85% | 4594.66 | 2247 / 2642 | 58% | 4.59 | 412 / 705 |
| adrenal gland | 7% | 72.47 | 18 / 258 | 55% | 5.15 | 126 / 230 |
| esophagus | 0% | 0 | 0 / 1445 | 9% | 0.18 | 16 / 183 |
| skin | 0% | 0.54 | 1 / 1809 | 6% | 0.13 | 30 / 472 |
| lung | 0% | 0 | 0 / 578 | 5% | 0.08 | 57 / 1155 |
| pancreas | 0% | 0 | 0 / 328 | 4% | 0.12 | 8 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.06 | 1 / 29 |
| ovary | 0% | 0 | 0 / 180 | 3% | 0.05 | 13 / 430 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.03 | 12 / 504 |
| thymus | 0% | 0 | 0 / 653 | 1% | 0.03 | 8 / 605 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.05 | 1 / 80 |
| breast | 0% | 0 | 0 / 459 | 1% | 0.13 | 13 / 1118 |
| intestine | 0% | 0 | 0 / 966 | 1% | 0.01 | 5 / 527 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.01 | 3 / 406 |
| stomach | 0% | 0 | 0 / 359 | 1% | 0.01 | 2 / 286 |
| uterus | 0% | 0 | 0 / 170 | 0% | 0.01 | 2 / 459 |
| prostate | 0% | 0 | 0 / 245 | 0% | 0.03 | 1 / 502 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.00 | 1 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071420 | Biological process | cellular response to histamine |
| GO_0009791 | Biological process | post-embryonic development |
| GO_1904862 | Biological process | inhibitory synapse assembly |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0030534 | Biological process | adult behavior |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0051932 | Biological process | synaptic transmission, GABAergic |
| GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1902495 | Cellular component | transmembrane transporter complex |
| GO_0098794 | Cellular component | postsynapse |
| GO_0043005 | Cellular component | neuron projection |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_1902711 | Cellular component | GABA-A receptor complex |
| GO_0030424 | Cellular component | axon |
| GO_0032590 | Cellular component | dendrite membrane |
| GO_0099634 | Cellular component | postsynaptic specialization membrane |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004890 | Molecular function | GABA-A receptor activity |
| GO_0030594 | Molecular function | neurotransmitter receptor activity |
| GO_0022851 | Molecular function | GABA-gated chloride ion channel activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0008503 | Molecular function | benzodiazepine receptor activity |
| Gene name | GABRG2 |
| Protein name | Gamma-aminobutyric acid type A receptor subunit gamma2 Gamma-aminobutyric acid type A receptor subunit gamma2 (cDNA FLJ59748, highly similar to Gamma-aminobutyric-acid receptor gamma-2 subunit) Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) |
| Synonyms | |
| Description | FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity . The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). . |
| Accessions | A0A1W2PSF4 ENST00000638660.1 A0A1W2PPS4 ENST00000639111.2 [P18507-1] A0A1W2PQA6 A0A1W2PP56 ENST00000638772.1 ENST00000638552.1 A0A1W2PRY3 ENST00000361925.9 ENST00000639384.1 A0A1W2PQR9 A0A1X7SBS5 A0A1W2PRM8 ENST00000638877.1 E5RGJ0 ENST00000523372.2 ENST00000640757.1 A0A286YFI6 A0A1W2PQX1 ENST00000640574.1 A0A1W2PRU1 P18507 A8MWU7 ENST00000639683.1 ENST00000640985.1 A0A1W2PQ81 ENST00000522990.5 ENST00000639424.1 E5RIG3 A0A1X7SBZ8 ENST00000639213.2 [P18507-2] ENST00000641017.1 A0A1W2PR49 ENST00000640910.1 ENST00000639046.1 ENST00000356592.8 A0A1W2PPN5 ENST00000639278.1 A0A1W2PRN4 ENST00000639975.1 ENST00000414552.6 [P18507-3] |
