MAPK8IP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0046328Biological processregulation of JNK cascade
GO_0046330Biological processpositive regulation of JNK cascade
GO_2000564Biological processregulation of CD8-positive, alpha-beta T cell proliferation
GO_0043508Biological processnegative regulation of JUN kinase activity
GO_0016192Biological processvesicle-mediated transport
GO_0006355Biological processregulation of DNA-templated transcription
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0044302Cellular componentdentate gyrus mossy fiber
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0008432Molecular functionJUN kinase binding
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameMAPK8IP1
Protein nameMitogen-activated protein kinase 8 interacting protein 1
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain 1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
SynonymsIB1
PRKM8IP
JIP1
DescriptionFUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells. .

AccessionsQ9UQF2
ENST00000395629.2
Q6NUQ9
ENST00000241014.6
E9PBB9