Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 13 studies | 69% ± 23% | |
oligodendrocyte precursor cell | 13 studies | 52% ± 20% | |
GABAergic neuron | 11 studies | 59% ± 23% | |
oligodendrocyte | 9 studies | 32% ± 16% | |
astrocyte | 6 studies | 36% ± 20% | |
interneuron | 6 studies | 61% ± 21% | |
ionocyte | 5 studies | 41% ± 15% | |
neuron | 5 studies | 52% ± 15% | |
adipocyte | 5 studies | 28% ± 11% | |
retina horizontal cell | 5 studies | 60% ± 26% | |
endothelial cell | 4 studies | 47% ± 20% | |
granule cell | 4 studies | 62% ± 15% | |
retinal bipolar neuron | 4 studies | 48% ± 27% | |
OFF-bipolar cell | 4 studies | 43% ± 28% | |
amacrine cell | 4 studies | 63% ± 2% | |
retinal ganglion cell | 4 studies | 49% ± 15% | |
GABAergic interneuron | 3 studies | 65% ± 3% | |
microglial cell | 3 studies | 44% ± 14% | |
GABAergic amacrine cell | 3 studies | 62% ± 14% | |
glycinergic amacrine cell | 3 studies | 54% ± 10% | |
rod bipolar cell | 3 studies | 79% ± 26% | |
ependymal cell | 3 studies | 34% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1967.41 | 2631 / 2642 | 95% | 7.22 | 668 / 705 |
thymus | 100% | 3541.73 | 651 / 653 | 61% | 4.67 | 370 / 605 |
skin | 34% | 273.72 | 614 / 1809 | 53% | 4.00 | 249 / 472 |
kidney | 27% | 99.07 | 24 / 89 | 46% | 3.40 | 415 / 901 |
breast | 21% | 72.53 | 96 / 459 | 29% | 0.61 | 328 / 1118 |
blood vessel | 49% | 324.13 | 653 / 1335 | 0% | 0 | 0 / 0 |
uterus | 36% | 155.79 | 61 / 170 | 11% | 0.68 | 50 / 459 |
heart | 46% | 336.31 | 393 / 861 | 0% | 0 | 0 / 0 |
adrenal gland | 5% | 15.53 | 12 / 258 | 39% | 1.09 | 90 / 230 |
intestine | 24% | 110.95 | 233 / 966 | 4% | 0.07 | 19 / 527 |
bladder | 19% | 106.71 | 4 / 21 | 6% | 0.25 | 28 / 504 |
esophagus | 13% | 45.44 | 181 / 1445 | 11% | 0.26 | 20 / 183 |
stomach | 12% | 39.16 | 43 / 359 | 11% | 0.25 | 31 / 286 |
adipose | 23% | 67.64 | 271 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 15% | 122.42 | 139 / 929 | 0% | 0 | 0 / 0 |
pancreas | 0% | 0.62 | 1 / 328 | 10% | 0.19 | 18 / 178 |
lung | 1% | 2.95 | 6 / 578 | 9% | 0.20 | 101 / 1155 |
eye | 0% | 0 | 0 / 0 | 9% | 0.17 | 7 / 80 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.12 | 2 / 29 |
prostate | 3% | 6.80 | 8 / 245 | 1% | 0.01 | 4 / 502 |
ovary | 0% | 0 | 0 / 180 | 1% | 0.07 | 5 / 430 |
liver | 0% | 0 | 0 / 226 | 1% | 0.03 | 4 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0046339 | Biological process | diacylglycerol metabolic process |
GO_0046834 | Biological process | lipid phosphorylation |
GO_0030168 | Biological process | platelet activation |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006654 | Biological process | phosphatidic acid biosynthetic process |
GO_0007205 | Biological process | protein kinase C-activating G protein-coupled receptor signaling pathway |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0043197 | Cellular component | dendritic spine |
GO_0016020 | Cellular component | membrane |
GO_0097060 | Cellular component | synaptic membrane |
GO_0030672 | Cellular component | synaptic vesicle membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0005634 | Cellular component | nucleus |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004143 | Molecular function | ATP-dependent diacylglycerol kinase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | DGKI |
Protein name | Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107) Diacylglycerol kinase iota |
Synonyms | |
Description | FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position . By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). . |
Accessions | E7EM72 A0A087WV00 E9PFX6 ENST00000453654.6 ENST00000446122.5 ENST00000288490.9 A0A9L9PXR3 ENST00000424189.6 E7EWQ4 ENST00000483619.1 O75912 ENST00000614521.2 |