DGKI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046339Biological processdiacylglycerol metabolic process
GO_0046834Biological processlipid phosphorylation
GO_0030168Biological processplatelet activation
GO_0035556Biological processintracellular signal transduction
GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0016020Cellular componentmembrane
GO_0097060Cellular componentsynaptic membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDGKI
Protein nameDiacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
Diacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107)
Diacylglycerol kinase iota
Synonyms
DescriptionFUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position . By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). .

AccessionsE7EM72
A0A087WV00
E9PFX6
ENST00000453654.6
ENST00000446122.5
ENST00000288490.9
A0A9L9PXR3
ENST00000424189.6
E7EWQ4
ENST00000483619.1
O75912
ENST00000614521.2