Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 8 studies | 39% ± 14% | |
| endothelial cell | 5 studies | 19% ± 5% | |
| myeloid cell | 5 studies | 21% ± 6% | |
| astrocyte | 4 studies | 28% ± 8% | |
| GABAergic neuron | 3 studies | 25% ± 2% | |
| glutamatergic neuron | 3 studies | 40% ± 15% |
Insufficient scRNA-seq data for expression of HRH1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 98% | 1203.39 | 950 / 966 | 98% | 11.32 | 519 / 527 |
| bladder | 100% | 1142.00 | 21 / 21 | 96% | 10.80 | 484 / 504 |
| uterus | 99% | 681.08 | 169 / 170 | 94% | 12.09 | 433 / 459 |
| lung | 98% | 855.92 | 565 / 578 | 95% | 8.13 | 1096 / 1155 |
| esophagus | 94% | 664.83 | 1357 / 1445 | 97% | 10.33 | 177 / 183 |
| ovary | 93% | 618.82 | 168 / 180 | 89% | 8.75 | 382 / 430 |
| breast | 96% | 758.73 | 441 / 459 | 85% | 5.20 | 954 / 1118 |
| brain | 59% | 352.46 | 1555 / 2642 | 97% | 17.91 | 686 / 705 |
| thymus | 72% | 252.07 | 467 / 653 | 75% | 7.39 | 456 / 605 |
| kidney | 55% | 288.52 | 49 / 89 | 89% | 12.90 | 799 / 901 |
| skin | 100% | 1151.83 | 1800 / 1809 | 42% | 2.56 | 198 / 472 |
| stomach | 37% | 244.90 | 132 / 359 | 95% | 8.92 | 271 / 286 |
| prostate | 74% | 506.56 | 181 / 245 | 54% | 2.52 | 271 / 502 |
| blood vessel | 99% | 1743.07 | 1328 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1110.41 | 1197 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 1% | 1.97 | 2 / 328 | 96% | 12.00 | 171 / 178 |
| adrenal gland | 26% | 118.40 | 68 / 258 | 62% | 12.36 | 143 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 8.46 | 39 / 45 |
| heart | 28% | 95.18 | 241 / 861 | 0% | 0 | 0 / 0 |
| spleen | 24% | 60.65 | 59 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 24% | 0.67 | 7 / 29 |
| muscle | 18% | 58.03 | 147 / 803 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 13% | 0.78 | 52 / 406 |
| peripheral blood | 0% | 0.39 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071420 | Biological process | cellular response to histamine |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0043114 | Biological process | regulation of vascular permeability |
| GO_0045907 | Biological process | positive regulation of vasoconstriction |
| GO_0098664 | Biological process | G protein-coupled serotonin receptor signaling pathway |
| GO_0008542 | Biological process | visual learning |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0007613 | Biological process | memory |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005829 | Cellular component | cytosol |
| GO_0045202 | Cellular component | synapse |
| GO_0030594 | Molecular function | neurotransmitter receptor activity |
| GO_0004993 | Molecular function | G protein-coupled serotonin receptor activity |
| GO_0004969 | Molecular function | histamine receptor activity |
| Gene name | HRH1 |
| Protein name | Histamine H1 receptor (H1R) (HH1R) Histamine receptor H1 |
| Synonyms | |
| Description | FUNCTION: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. |
| Accessions | C9J2E6 ENST00000431010.3 ENST00000397056.1 ENST00000413416.1 ENST00000438284.2 P35367 |
