MME | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
adipocyte	10 studies	43% ± 21%	Explore
epithelial cell of proximal tubule	8 studies	36% ± 18%	Explore
fibroblast	6 studies	29% ± 25%	Explore
podocyte	6 studies	85% ± 18%	Explore
enterocyte	6 studies	36% ± 9%	Explore
precursor B cell	6 studies	48% ± 9%	Explore
pro-B cell	5 studies	55% ± 14%	Explore
alveolar macrophage	5 studies	25% ± 10%	Explore
B cell	4 studies	24% ± 6%	Explore
epithelial cell	4 studies	31% ± 9%	Explore
neutrophil	3 studies	25% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	95%	5669.75	232 / 245	93%	54.15	469 / 502
kidney	91%	13321.27	81 / 89	74%	29.60	663 / 901
breast	99%	6004.69	454 / 459	62%	9.70	693 / 1118
lung	96%	4835.86	556 / 578	40%	8.34	465 / 1155
liver	74%	1897.11	168 / 226	34%	14.64	138 / 406
muscle	97%	2732.64	778 / 803	0%	0	0 / 0
adipose	91%	5238.38	1096 / 1204	0%	0	0 / 0
bladder	38%	522.71	8 / 21	53%	13.07	266 / 504
skin	38%	38896.13	691 / 1809	46%	28.04	219 / 472
peripheral blood	75%	6437.26	696 / 929	0%	0	0 / 0
intestine	15%	1986.02	143 / 966	34%	6.71	178 / 527
uterus	15%	510.02	25 / 170	33%	11.00	153 / 459
esophagus	15%	314.54	216 / 1445	31%	6.06	57 / 183
lymph node	0%	0	0 / 0	41%	8.70	12 / 29
stomach	2%	78.58	8 / 359	38%	8.97	109 / 286
pancreas	0%	5.04	1 / 328	34%	4.64	60 / 178
spleen	32%	462.78	76 / 241	0%	0	0 / 0
thymus	8%	123.86	53 / 653	15%	2.09	89 / 605
eye	0%	0	0 / 0	21%	9.46	17 / 80
adrenal gland	1%	16.67	3 / 258	20%	3.89	46 / 230
brain	16%	400.04	418 / 2642	5%	0.49	32 / 705
ovary	2%	25.93	3 / 180	17%	2.38	74 / 430
tonsil	0%	0	0 / 0	13%	1.03	6 / 45
heart	10%	120.11	83 / 861	0%	0	0 / 0
blood vessel	9%	223.38	122 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0019233	Biological process	sensory perception of pain
GO_0030324	Biological process	lung development
GO_0010815	Biological process	bradykinin catabolic process
GO_0043627	Biological process	response to estrogen
GO_0050435	Biological process	amyloid-beta metabolic process
GO_0007611	Biological process	learning or memory
GO_0050769	Biological process	positive regulation of neurogenesis
GO_0001822	Biological process	kidney development
GO_0016485	Biological process	protein processing
GO_0090399	Biological process	replicative senescence
GO_0046449	Biological process	creatinine metabolic process
GO_0042447	Biological process	hormone catabolic process
GO_0001890	Biological process	placenta development
GO_0071493	Biological process	cellular response to UV-B
GO_0097242	Biological process	amyloid-beta clearance
GO_0010814	Biological process	substance P catabolic process
GO_0071345	Biological process	cellular response to cytokine stimulus
GO_0006508	Biological process	proteolysis
GO_0150094	Biological process	amyloid-beta clearance by cellular catabolic process
GO_1900273	Biological process	positive regulation of long-term synaptic potentiation
GO_0030163	Biological process	protein catabolic process
GO_0006518	Biological process	peptide metabolic process
GO_0061837	Biological process	neuropeptide processing
GO_0071492	Biological process	cellular response to UV-A
GO_0005903	Cellular component	brush border
GO_0030667	Cellular component	secretory granule membrane
GO_0098793	Cellular component	presynapse
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0005769	Cellular component	early endosome
GO_0070062	Cellular component	extracellular exosome
GO_0043025	Cellular component	neuronal cell body
GO_0005925	Cellular component	focal adhesion
GO_0030425	Cellular component	dendrite
GO_0005802	Cellular component	trans-Golgi network
GO_0009986	Cellular component	cell surface
GO_0008021	Cellular component	synaptic vesicle
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_0044306	Cellular component	neuron projection terminus
GO_0042803	Molecular function	protein homodimerization activity
GO_0004175	Molecular function	endopeptidase activity
GO_0042277	Molecular function	peptide binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0008270	Molecular function	zinc ion binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_1901612	Molecular function	cardiolipin binding
GO_0070012	Molecular function	oligopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0008238	Molecular function	exopeptidase activity

IV. Literature review

[source]

Gene name	MME
Protein name	Alternative protein MME Neprilysin-411 (EC 3.4.24.11) MME protein (Membrane metallo-endopeptidase variant 2) (Membrane metalloendopeptidase) Neprilysin-390 (EC 3.4.24.11) Neprilysin Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (Skin fibroblast elastase)
Synonyms	EPN
Description	FUNCTION: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids . Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond . Catalyzes cleavage of bradykinin, substance P and neurotensin peptides . Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 . Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) . Displays UV-inducible elastase activity toward skin preelastic and elastic fibers . .
Accessions	ENST00000675418.2 C9JDZ3 ENST00000382989.7 ENST00000680282.1 L7Z660 Q3KQS6 P08473 ENST00000492661.5 ENST00000473730 A0A7I2U302 ENST00000473730.6 ENST00000615825.2 ENST00000493237.5 L7ZC27 ENST00000491026 ENST00000680057.1 L8E8E1 B7ZKY6 C9IYX7 ENST00000462745.5 ENST00000491026.6 ENST00000675418 A0A6Q8PFY6 ENST00000460393.6 ENST00000360490.7

MME report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review