CHRM3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	69% ± 22%	Explore
GABAergic neuron	11 studies	52% ± 23%	Explore
endothelial cell	10 studies	38% ± 20%	Explore
oligodendrocyte precursor cell	8 studies	32% ± 16%	Explore
neuron	7 studies	31% ± 16%	Explore
interneuron	6 studies	42% ± 29%	Explore
capillary endothelial cell	4 studies	26% ± 9%	Explore
glomerular endothelial cell	3 studies	27% ± 4%	Explore
GABAergic interneuron	3 studies	77% ± 12%	Explore
granule cell	3 studies	29% ± 14%	Explore
microglial cell	3 studies	36% ± 16%	Explore
endothelial cell of vascular tree	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	39% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	1771.67	359 / 359	75%	3.96	215 / 286
intestine	92%	1903.06	890 / 966	80%	3.54	420 / 527
esophagus	86%	2404.62	1249 / 1445	84%	4.68	154 / 183
pancreas	100%	1683.56	328 / 328	46%	1.23	82 / 178
thymus	91%	455.16	596 / 653	51%	1.45	311 / 605
bladder	90%	2861.10	19 / 21	46%	1.68	233 / 504
ovary	88%	687.99	158 / 180	27%	0.69	116 / 430
prostate	50%	303.35	122 / 245	60%	4.95	300 / 502
brain	59%	888.92	1546 / 2642	49%	2.45	346 / 705
kidney	66%	245.69	59 / 89	32%	1.02	290 / 901
lung	44%	164.19	252 / 578	55%	2.52	633 / 1155
uterus	56%	281.62	96 / 170	28%	0.91	127 / 459
skin	44%	253.33	791 / 1809	29%	1.58	138 / 472
adrenal gland	5%	16.45	14 / 258	45%	2.48	104 / 230
tonsil	0%	0	0 / 0	40%	0.96	18 / 45
breast	18%	52.20	82 / 459	16%	1.04	181 / 1118
liver	10%	31.24	23 / 226	22%	0.57	88 / 406
blood vessel	18%	65.01	235 / 1335	0%	0	0 / 0
spleen	16%	49.01	39 / 241	0%	0	0 / 0
adipose	4%	16.86	52 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
heart	3%	7.27	23 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.03	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006939	Biological process	smooth muscle contraction
GO_0007197	Biological process	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
GO_0007213	Biological process	G protein-coupled acetylcholine receptor signaling pathway
GO_0019722	Biological process	calcium-mediated signaling
GO_0007207	Biological process	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO_0007165	Biological process	signal transduction
GO_0046541	Biological process	saliva secretion
GO_0095500	Biological process	acetylcholine receptor signaling pathway
GO_0006940	Biological process	regulation of smooth muscle contraction
GO_1990806	Biological process	ligand-gated ion channel signaling pathway
GO_0098664	Biological process	G protein-coupled serotonin receptor signaling pathway
GO_0032412	Biological process	regulation of monoatomic ion transmembrane transporter activity
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0045987	Biological process	positive regulation of smooth muscle contraction
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0036211	Biological process	protein modification process
GO_0007268	Biological process	chemical synaptic transmission
GO_0007187	Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0007271	Biological process	synaptic transmission, cholinergic
GO_0007399	Biological process	nervous system development
GO_0099105	Biological process	ion channel modulating, G protein-coupled receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0009925	Cellular component	basal plasma membrane
GO_0030425	Cellular component	dendrite
GO_0045202	Cellular component	synapse
GO_0045211	Cellular component	postsynaptic membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0038023	Molecular function	signaling receptor activity
GO_0004435	Molecular function	phosphatidylinositol phospholipase C activity
GO_0042166	Molecular function	acetylcholine binding
GO_0004993	Molecular function	G protein-coupled serotonin receptor activity
GO_0016907	Molecular function	G protein-coupled acetylcholine receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CHRM3
Protein name	Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M3 muscarinic receptor Cholinergic receptor muscarinic 3
Synonyms
Description	FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. . FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. .
Accessions	P20309 ENST00000255380.8 Q96RG9 ENST00000676433.1 ENST00000675709.1 ENST00000676153.1 ENST00000675184.1 Q8NG01 ENST00000615928.5 B1AN12 A0A6Q8PG67 ENST00000448020.1

CHRM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review