phosphatidylinositol phospholipase C activity

I. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1CCL5-CCR1CCL5_HUMAN - CCR1_HUMANLigand-ReceptorSignaling by Chemokines
2CCL5-CCR5CCL5_HUMAN - CCR5_HUMANLigand-ReceptorSignaling by Chemokines

II. Literature review

[source]
Namephosphatidylinositol phospholipase C activity
IDGO_0004435
collection_id

Molecular function

Exact synonym

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity

Description

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+.

Related synonym

1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity, PI-PLC activity, phosphatidylinositol-4,5-bisphosphate hydrolysis, phosphoinositidase C activity, phosphoinositide phospholipase C activity

External URL
Genes
PLCD3PLCB4CCL5PLCL1PLCZ1PLCH2CCR1PLCG1PLCH1PLCB3PLCD4PLCB2GDPD5EDNRACCR5CHRM1PLCG2CHRM5PLCE1PLCD1CASRPLCB1F2RL2CHRM3PLCL2BDKRB2