PLCG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046488Biological processphosphatidylinositol metabolic process
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0019722Biological processcalcium-mediated signaling
GO_0001701Biological processin utero embryonic development
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0045766Biological processpositive regulation of angiogenesis
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0050852Biological processT cell receptor signaling pathway
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0016477Biological processcell migration
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0009395Biological processphospholipid catabolic process
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0008180Cellular componentCOP9 signalosome
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0030027Cellular componentlamellipodium
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019901Molecular functionprotein kinase binding
GO_0004435Molecular functionphosphatidylinositol phospholipase C activity
GO_0004629Molecular functionphospholipase C activity
GO_0050429Molecular functioncalcium-dependent phospholipase C activity
GO_0035254Molecular functionglutamate receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0005168Molecular functionneurotrophin TRKA receptor binding

IV. Literature review

[source]
Gene namePLCG1
Protein namePhospholipase C gamma 1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Phosphoinositide phospholipase C (EC 3.1.4.11)
SynonymsPLC1
protein
variant
DescriptionFUNCTION: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration . Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity). .

AccessionsV9GYH5
A0A0D9SEK2
V9GY71
M0QX77
ENST00000607954.1
ENST00000609257.5
ENST00000244007.7 [P19174-2]
ENST00000373271.5 [P19174-1]
ENST00000685551.1 [P19174-2]
ENST00000608885.5
V9GY63
P19174
ENST00000599785.5
Q4LE43
ENST00000612731.2