Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 21 studies | 34% ± 17% | |
astrocyte | 14 studies | 35% ± 14% | |
smooth muscle cell | 11 studies | 31% ± 12% | |
oligodendrocyte precursor cell | 11 studies | 35% ± 18% | |
fibroblast | 9 studies | 23% ± 6% | |
endothelial cell of lymphatic vessel | 8 studies | 37% ± 14% | |
type I pneumocyte | 7 studies | 32% ± 11% | |
GABAergic neuron | 6 studies | 29% ± 11% | |
endothelial cell | 6 studies | 45% ± 20% | |
epithelial cell | 6 studies | 30% ± 10% | |
Mueller cell | 6 studies | 46% ± 19% | |
podocyte | 5 studies | 63% ± 26% | |
adipocyte | 5 studies | 24% ± 6% | |
deuterosomal cell | 4 studies | 25% ± 10% | |
retinal pigment epithelial cell | 4 studies | 53% ± 26% | |
ciliated cell | 4 studies | 22% ± 4% | |
glutamatergic neuron | 4 studies | 22% ± 5% | |
interstitial cell of Cajal | 3 studies | 38% ± 24% | |
glial cell | 3 studies | 38% ± 15% | |
progenitor cell | 3 studies | 27% ± 6% | |
respiratory goblet cell | 3 studies | 21% ± 2% | |
ependymal cell | 3 studies | 53% ± 12% | |
Schwann cell | 3 studies | 43% ± 24% | |
interneuron | 3 studies | 36% ± 8% | |
neuron | 3 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 2902.21 | 359 / 359 | 93% | 6.40 | 266 / 286 |
intestine | 100% | 3634.81 | 966 / 966 | 92% | 6.13 | 485 / 527 |
brain | 90% | 971.09 | 2387 / 2642 | 99% | 8.04 | 695 / 705 |
pancreas | 96% | 1439.05 | 315 / 328 | 93% | 6.13 | 165 / 178 |
thymus | 100% | 4184.81 | 652 / 653 | 87% | 9.81 | 527 / 605 |
bladder | 100% | 2341.76 | 21 / 21 | 79% | 6.14 | 398 / 504 |
kidney | 100% | 2857.17 | 89 / 89 | 79% | 4.33 | 709 / 901 |
ovary | 99% | 1752.79 | 179 / 180 | 74% | 4.02 | 317 / 430 |
lung | 100% | 2905.28 | 576 / 578 | 74% | 4.19 | 849 / 1155 |
uterus | 100% | 3756.65 | 170 / 170 | 72% | 5.27 | 330 / 459 |
esophagus | 92% | 2516.32 | 1328 / 1445 | 80% | 6.06 | 146 / 183 |
breast | 97% | 1276.98 | 446 / 459 | 68% | 4.26 | 757 / 1118 |
prostate | 100% | 1757.40 | 244 / 245 | 63% | 2.14 | 318 / 502 |
adrenal gland | 74% | 635.75 | 190 / 258 | 71% | 4.32 | 163 / 230 |
skin | 63% | 538.05 | 1131 / 1809 | 41% | 2.06 | 194 / 472 |
blood vessel | 100% | 4926.29 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2743.92 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.09 | 1 / 1 |
adipose | 99% | 1517.91 | 1187 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 2638.09 | 839 / 861 | 0% | 0 | 0 / 0 |
muscle | 77% | 957.12 | 616 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 42% | 1.76 | 19 / 45 |
liver | 3% | 18.18 | 7 / 226 | 30% | 1.14 | 122 / 406 |
eye | 0% | 0 | 0 / 0 | 13% | 0.40 | 10 / 80 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.07 | 1 / 29 |
peripheral blood | 1% | 7.23 | 13 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0046488 | Biological process | phosphatidylinositol metabolic process |
GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
GO_0019722 | Biological process | calcium-mediated signaling |
GO_0010592 | Biological process | positive regulation of lamellipodium assembly |
GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
GO_0048015 | Biological process | phosphatidylinositol-mediated signaling |
GO_0016042 | Biological process | lipid catabolic process |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006651 | Biological process | diacylglycerol biosynthetic process |
GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
GO_0032835 | Biological process | glomerulus development |
GO_0005886 | Cellular component | plasma membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005829 | Cellular component | cytosol |
GO_0030027 | Cellular component | lamellipodium |
GO_0019899 | Molecular function | enzyme binding |
GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
GO_0031267 | Molecular function | small GTPase binding |
GO_0004435 | Molecular function | phosphatidylinositol phospholipase C activity |
GO_0004629 | Molecular function | phospholipase C activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PLCE1 |
Protein name | Phospholipase C epsilon 1 Alternative protein PLCE1 Phosphoinositide phospholipase C (EC 3.1.4.11) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) |
Synonyms | KIAA1516 PLCE PPLC |
Description | FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly . . |
Accessions | A0A6Q8PH04 A0A8I5KXT2 ENST00000674738.1 L8EAV1 A0A8I5KV08 A0A6Q8PHP9 A0A8I5KVG7 A0A6Q8PGT4 ENST00000371375.2 [Q9P212-2] ENST00000685253.1 ENST00000675218.1 [Q9P212-2] ENST00000686954.1 ENST00000692396.1 A0A7I2PPM5 A0A6Q8PFG0 B7ZM61 A0A6Q8PHN3 ENST00000676102.1 ENST00000371385.8 ENST00000675487.1 A0A8I5KQ92 ENST00000692286.1 ENST00000371380.8 [Q9P212-1] ENST00000675718.1 Q9P212 ENST00000688810.1 ENST00000674827.1 |