PLCE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0046488Biological processphosphatidylinositol metabolic process
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0019722Biological processcalcium-mediated signaling
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0016042Biological processlipid catabolic process
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0006651Biological processdiacylglycerol biosynthetic process
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0032835Biological processglomerulus development
GO_0005886Cellular componentplasma membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0019899Molecular functionenzyme binding
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0031267Molecular functionsmall GTPase binding
GO_0004435Molecular functionphosphatidylinositol phospholipase C activity
GO_0004629Molecular functionphospholipase C activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLCE1
Protein namePhospholipase C epsilon 1
Alternative protein PLCE1
Phosphoinositide phospholipase C (EC 3.1.4.11)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)
SynonymsKIAA1516
PLCE
PPLC
DescriptionFUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly . .

AccessionsA0A6Q8PH04
A0A8I5KXT2
ENST00000674738.1
L8EAV1
A0A8I5KV08
A0A6Q8PHP9
A0A8I5KVG7
A0A6Q8PGT4
ENST00000371375.2 [Q9P212-2]
ENST00000685253.1
ENST00000675218.1 [Q9P212-2]
ENST00000686954.1
ENST00000692396.1
A0A7I2PPM5
A0A6Q8PFG0
B7ZM61
A0A6Q8PHN3
ENST00000676102.1
ENST00000371385.8
ENST00000675487.1
A0A8I5KQ92
ENST00000692286.1
ENST00000371380.8 [Q9P212-1]
ENST00000675718.1
Q9P212
ENST00000688810.1
ENST00000674827.1