interstitial cell of Cajal report

I. Related cell sub types

II. Gene markers

Gene
Number of
supported studies
Average coverage
Other major groups
(express this gene)
Other cell types
(express this gene)
ANO1345% ± 28%26
Explore
FBN2344% ± 5%410
Explore
COL5A2346% ± 4%417
Explore
LAMA4337% ± 8%421
Explore

III. Associated gene sets

GO_0097049Biological processmotor neuron apoptotic process
GO_0003100Biological processregulation of systemic arterial blood pressure by endothelin
GO_0070828Biological processheterochromatin organization
GO_0060538Biological processskeletal muscle organ development
GO_0060585Biological processpositive regulation of prostaglandin-endoperoxide synthase activity
GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0010961Biological processintracellular magnesium ion homeostasis
GO_0014826Biological processvein smooth muscle contraction
GO_0018057Biological processpeptidyl-lysine oxidation
GO_0090131Biological processmesenchyme migration
GO_0030072Biological processpeptide hormone secretion
GO_0048070Biological processregulation of developmental pigmentation
GO_0003360Biological processbrainstem development
GO_0007548Biological processsex differentiation
GO_0002690Biological processpositive regulation of leukocyte chemotaxis
GO_2000672Biological processnegative regulation of motor neuron apoptotic process

IV. Literature review

[source]
Cell type nameinterstitial cell of Cajal
SynonymsICC
intestinal pacemaker cell
DescriptionThis is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.
ParentCL_0000075