FBN2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBN2 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0060346Biological processbone trabecula formation
GO_0043010Biological processcamera-type eye development
GO_0035583Biological processsequestering of TGFbeta in extracellular matrix
GO_0048048Biological processembryonic eye morphogenesis
GO_0030326Biological processembryonic limb morphogenesis
GO_0030501Biological processpositive regulation of bone mineralization
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0009653Biological processanatomical structure morphogenesis
GO_0001527Cellular componentmicrofibril
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0030023Molecular functionextracellular matrix constituent conferring elasticity
GO_0005509Molecular functioncalcium ion binding
GO_0005179Molecular functionhormone activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBN2
Protein nameFibrillin 2
Alternative protein FBN2
Fibrillin-2
Fibrillin-2 [Cleaved into: Placensin]
Synonyms
DescriptionFUNCTION: [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. .; FUNCTION: [Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness . Has glucogenic activity: is able to increase plasma glucose levels (By similarity). .

AccessionsL8E8V5
D6RJI3
A0A6B9XMH6
A0A6B9XP50
ENST00000262464.9 [P35556-1]
ENST00000502468.5
E9PHW4
ENST00000508053.6
P35556
ENST00000508989.5
L8E7B8
A0A9H4AZX0