Biological process

negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta, negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta, sequestering of TGFbeta LLC in extracellular matrix, sequestering of TGFbeta large latency complex in extracellular matrix

Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.