LTBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035592Biological processestablishment of protein localization to extracellular region
GO_0007178Biological processcell surface receptor protein serine/threonine kinase signaling pathway
GO_0035583Biological processsequestering of TGFbeta in extracellular matrix
GO_0001527Cellular componentmicrofibril
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0032991Cellular componentprotein-containing complex
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0005201Molecular functionextracellular matrix structural constituent
GO_0050436Molecular functionmicrofibril binding
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0141069Molecular functionreceptor ligand inhibitor activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0005024Molecular functiontransforming growth factor beta receptor activity

IV. Literature review

[source]
Gene nameLTBP1
Protein nameLTBP1 protein
Latent transforming growth factor beta binding protein 1
Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)
Synonyms
DescriptionFUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space . Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta . Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta . .

AccessionsC9JD84
Q14766
H7C4L5
H7C0I7
ENST00000422669.1
ENST00000413303.5
C9JDW2
ENST00000432635.1
B7ZLY3
ENST00000468091.2
ENST00000402934.5
ENST00000404816.7 [Q14766-1]
H7BZ76
ENST00000415140.6
ENST00000404525.5 [Q14766-3]
ENST00000407925.5 [Q14766-2]
H7C2H7
ENST00000418533.6
E7EV71