Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 30 studies | 35% ± 15% | |
smooth muscle cell | 25 studies | 39% ± 16% | |
endothelial cell | 18 studies | 27% ± 9% | |
astrocyte | 13 studies | 39% ± 17% | |
myofibroblast cell | 12 studies | 49% ± 18% | |
pericyte | 12 studies | 28% ± 12% | |
oligodendrocyte | 9 studies | 28% ± 14% | |
connective tissue cell | 6 studies | 26% ± 7% | |
endothelial cell of artery | 6 studies | 22% ± 6% | |
cardiac muscle cell | 6 studies | 57% ± 21% | |
oligodendrocyte precursor cell | 6 studies | 27% ± 10% | |
megakaryocyte | 5 studies | 75% ± 14% | |
platelet | 5 studies | 30% ± 10% | |
adventitial cell | 5 studies | 31% ± 8% | |
endothelial cell of lymphatic vessel | 5 studies | 18% ± 3% | |
GABAergic neuron | 5 studies | 28% ± 11% | |
vein endothelial cell | 4 studies | 23% ± 8% | |
adipocyte | 4 studies | 28% ± 9% | |
epithelial cell | 4 studies | 29% ± 14% | |
endothelial cell of vascular tree | 4 studies | 22% ± 8% | |
glutamatergic neuron | 4 studies | 31% ± 7% | |
glial cell | 3 studies | 21% ± 5% | |
hepatocyte | 3 studies | 45% ± 25% | |
ependymal cell | 3 studies | 49% ± 11% | |
neuron | 3 studies | 20% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 95% | 9742.29 | 20 / 21 | 93% | 40.41 | 468 / 504 |
lung | 93% | 6787.64 | 537 / 578 | 95% | 50.95 | 1099 / 1155 |
uterus | 97% | 11889.44 | 165 / 170 | 89% | 47.03 | 409 / 459 |
prostate | 81% | 8118.78 | 199 / 245 | 98% | 51.95 | 492 / 502 |
esophagus | 71% | 11530.58 | 1023 / 1445 | 92% | 52.96 | 168 / 183 |
intestine | 70% | 4857.71 | 675 / 966 | 89% | 30.73 | 467 / 527 |
breast | 55% | 2934.78 | 253 / 459 | 93% | 37.44 | 1039 / 1118 |
ovary | 63% | 3827.66 | 113 / 180 | 80% | 24.50 | 343 / 430 |
stomach | 52% | 6451.98 | 188 / 359 | 88% | 37.45 | 253 / 286 |
skin | 46% | 16019.57 | 840 / 1809 | 54% | 16.68 | 255 / 472 |
blood vessel | 100% | 69444.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.03 | 1 / 1 |
pancreas | 1% | 42.82 | 3 / 328 | 96% | 62.77 | 171 / 178 |
heart | 91% | 10402.55 | 787 / 861 | 0% | 0 | 0 / 0 |
kidney | 25% | 2466.22 | 22 / 89 | 61% | 22.49 | 549 / 901 |
tonsil | 0% | 0 | 0 / 0 | 82% | 42.12 | 37 / 45 |
brain | 1% | 61.30 | 33 / 2642 | 76% | 21.30 | 539 / 705 |
thymus | 11% | 565.60 | 70 / 653 | 56% | 16.01 | 340 / 605 |
lymph node | 0% | 0 | 0 / 0 | 62% | 11.52 | 18 / 29 |
adrenal gland | 9% | 288.86 | 22 / 258 | 50% | 11.71 | 115 / 230 |
adipose | 48% | 2910.71 | 582 / 1204 | 0% | 0 | 0 / 0 |
liver | 3% | 122.61 | 7 / 226 | 38% | 9.92 | 155 / 406 |
eye | 0% | 0 | 0 / 0 | 28% | 4.44 | 22 / 80 |
muscle | 8% | 329.24 | 65 / 803 | 0% | 0 | 0 / 0 |
spleen | 4% | 182.57 | 10 / 241 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035592 | Biological process | establishment of protein localization to extracellular region |
GO_0007178 | Biological process | cell surface receptor protein serine/threonine kinase signaling pathway |
GO_0035583 | Biological process | sequestering of TGFbeta in extracellular matrix |
GO_0001527 | Cellular component | microfibril |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005576 | Cellular component | extracellular region |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0031012 | Cellular component | extracellular matrix |
GO_0005201 | Molecular function | extracellular matrix structural constituent |
GO_0050436 | Molecular function | microfibril binding |
GO_0050431 | Molecular function | transforming growth factor beta binding |
GO_0141069 | Molecular function | receptor ligand inhibitor activity |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0005024 | Molecular function | transforming growth factor beta receptor activity |
Gene name | LTBP1 |
Protein name | LTBP1 protein Latent transforming growth factor beta binding protein 1 Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) |
Synonyms | |
Description | FUNCTION: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space . Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta . Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta . . |
Accessions | C9JD84 Q14766 H7C4L5 H7C0I7 ENST00000422669.1 ENST00000413303.5 C9JDW2 ENST00000432635.1 B7ZLY3 ENST00000468091.2 ENST00000402934.5 ENST00000404816.7 [Q14766-1] H7BZ76 ENST00000415140.6 ENST00000404525.5 [Q14766-3] ENST00000407925.5 [Q14766-2] H7C2H7 ENST00000418533.6 E7EV71 |