NRROS report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NRROS at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0014005Biological processmicroglia development
GO_0035583Biological processsequestering of TGFbeta in extracellular matrix
GO_0006801Biological processsuperoxide metabolic process
GO_0006954Biological processinflammatory response
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0045087Biological processinnate immune response
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0050431Molecular functiontransforming growth factor beta binding
GO_0141069Molecular functionreceptor ligand inhibitor activity

IV. Literature review

[source]
Gene nameNRROS
Protein nameTransforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)
SynonymsUNQ3030/PRO9833
LRRC33
DescriptionFUNCTION: Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling . .

AccessionsQ86YC3
ENST00000328557.5