ANO1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ANO1 at tissue level.

III. Associated gene sets

GO_1901653Biological processcellular response to peptide
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0006821Biological processchloride transport
GO_0034605Biological processcellular response to heat
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0015705Biological processiodide transport
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_1902476Biological processchloride transmembrane transport
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0106091Biological processglial cell projection elongation
GO_0070254Biological processmucus secretion
GO_0072657Biological processprotein localization to membrane
GO_0016324Cellular componentapical plasma membrane
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0034707Cellular componentchloride channel complex
GO_0042995Cellular componentcell projection
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005247Molecular functionvoltage-gated chloride channel activity
GO_0015111Molecular functioniodide transmembrane transporter activity
GO_0005229Molecular functionintracellularly calcium-gated chloride channel activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0005254Molecular functionchloride channel activity
GO_0005227Molecular functioncalcium-activated cation channel activity

IV. Literature review

[source]
Gene nameANO1
Protein nameAnoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2)
Anoctamin
Anoctamin 1
SynonymsORAOV2
TAOS2
TMEM16A
DOG1
DescriptionFUNCTION: Calcium-activated chloride channel (CaCC) . Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression . Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC . However, was shown in another study not to be required for MUC5AC expression . Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity). .; FUNCTION: [Isoform 4]: Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability. .; FUNCTION: [Isoform 5]: Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+). .

AccessionsQ5XXA6
E9PP68
Q8NCT7
ENST00000355303.10 [Q5XXA6-1]
E9PS90
ENST00000531349.6 [Q5XXA6-5]
ENST00000531604.5
ENST00000531300.1
ENST00000530676.5 [Q5XXA6-2]
ENST00000316296.9 [Q5XXA6-3]