CCR5 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCR5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	452.11	576 / 578	90%	10.21	1045 / 1155
stomach	94%	168.01	338 / 359	77%	5.89	219 / 286
intestine	93%	208.04	897 / 966	69%	4.90	366 / 527
breast	70%	69.83	322 / 459	92%	12.41	1024 / 1118
thymus	91%	141.81	597 / 653	70%	5.38	423 / 605
prostate	93%	146.63	228 / 245	65%	3.45	328 / 502
kidney	69%	90.04	61 / 89	84%	13.34	754 / 901
uterus	79%	74.07	135 / 170	71%	7.18	327 / 459
pancreas	66%	55.87	216 / 328	78%	7.13	138 / 178
bladder	76%	132.19	16 / 21	62%	5.17	314 / 504
esophagus	80%	88.86	1162 / 1445	55%	2.81	101 / 183
liver	75%	60.83	169 / 226	41%	2.57	168 / 406
ovary	56%	44.26	100 / 180	58%	3.18	248 / 430
adrenal gland	88%	109.32	228 / 258	21%	0.83	48 / 230
skin	27%	16.83	495 / 1809	75%	12.22	352 / 472
lymph node	0%	0	0 / 0	100%	48.07	29 / 29
spleen	100%	961.71	241 / 241	0%	0	0 / 0
adipose	92%	144.81	1102 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	17.32	41 / 45
brain	40%	41.29	1058 / 2642	50%	3.58	349 / 705
peripheral blood	85%	330.14	792 / 929	0%	0	0 / 0
blood vessel	66%	84.97	880 / 1335	0%	0	0 / 0
heart	45%	34.97	387 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	19%	1.84	15 / 80
muscle	5%	2.33	37 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002407	Biological process	dendritic cell chemotaxis
GO_0070723	Biological process	response to cholesterol
GO_0006954	Biological process	inflammatory response
GO_2000110	Biological process	negative regulation of macrophage apoptotic process
GO_0019722	Biological process	calcium-mediated signaling
GO_0000165	Biological process	MAPK cascade
GO_0006935	Biological process	chemotaxis
GO_0006968	Biological process	cellular defense response
GO_0007267	Biological process	cell-cell signaling
GO_0006955	Biological process	immune response
GO_0046718	Biological process	symbiont entry into host cell
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0014808	Biological process	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0006816	Biological process	calcium ion transport
GO_0060326	Biological process	cell chemotaxis
GO_0023052	Biological process	signaling
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_0005768	Cellular component	endosome
GO_0015026	Molecular function	coreceptor activity
GO_0042802	Molecular function	identical protein binding
GO_0001618	Molecular function	virus receptor activity
GO_0004435	Molecular function	phosphatidylinositol phospholipase C activity
GO_0016493	Molecular function	C-C chemokine receptor activity
GO_0004950	Molecular function	chemokine receptor activity
GO_0019957	Molecular function	C-C chemokine binding
GO_0071791	Molecular function	chemokine (C-C motif) ligand 5 binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	CCR5
Protein name	C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) C-C chemokine receptor type 5 CCR5 Mutant C-C motif chemokine receptor Mutant chemokine receptor CCR5 Mutant chemokine receptor 5 Chemokine receptor 5 CC chemokine receptor 5 Chemokine receptor CCR5
Synonyms	hCG_15321 CMKBR5
Description	FUNCTION: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor . .; FUNCTION: (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1. .
Accessions	A0A089G3N1 H9MHK7 A0A089G3M1 A0A089G7J0 A0A089H960 L7S2Y4 A0A089G5R6 B2KIU2 B0EX00 Q9UN26 B8LFN8 Q5KSY4 H9MHP6 A0A089G7G0 J7HKA4 H9MHP5 A0A089G3M8 A0A089G7G9 A0A089H9A2 Q5EKN0 E7BJ57 A0A089G3P0 J7HGK0 Q5QIN9 A0A089G7G7 B2KIU1 J7HDH6 P51681 Q9UBJ7 A0A089G6S6 Q5QIP0 H9MHP4 A0A089H953 A0A089G3L9 Q9UN23 H9MHP9 A0A089G5N2 J7HJP8 A0A089H970 A0A089H987 A0A089H989 Q3L3Q6 A0A089G6R7 Q5QIP1 A0A089G5Q8 Q9UN25 A0A089G7J6 ENST00000292303.5 J7HDH2 B2KIU0 A0A089G6P0 A0A089H978 Q9UN27 A0A089G3K0 A0A089G5S5 J7HJP1 A0A089G5S8 Q9UBT9 H9MHP8 A0A089G5R7 A0A089G6R5 A0A089G7F7 A0A089G6P4 A0A089G6S3 B8LFP0 A1A490 Q9P1T8 ENST00000445772.1 A0A089H976 B8LFN9 A0A089G7H9 A0A089G3K4 H9MHP3 A0A089G7J3 Q5KSY5 A0A089G3M5 A0A089G7H7 A0A089G3P4 Q9UN24 A0A089G6S0 A0A089H974 Q9UN28 Q9P1T5 A0A089G6S9 B2KKJ9 A0A089H983 A0A089G5M8 Q9P1T4 A0A089G3N4 A0A089G3J8 Q5EKM8 Q38L21 A0A089G6Q9 A0A089H947 O14694 A0A089G5R2 J7HDE9 A0A089H958 Q5EKM9 B0EX01

CCR5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review