Insufficient scRNA-seq data for expression of PLCD3 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 4896.25 | 2640 / 2642 | 100% | 82.30 | 703 / 705 |
| esophagus | 100% | 3930.73 | 1445 / 1445 | 97% | 48.42 | 178 / 183 |
| ovary | 100% | 4109.59 | 180 / 180 | 97% | 60.22 | 415 / 430 |
| intestine | 98% | 5243.51 | 949 / 966 | 98% | 48.40 | 514 / 527 |
| stomach | 97% | 3586.42 | 350 / 359 | 94% | 46.47 | 268 / 286 |
| bladder | 100% | 6748.52 | 21 / 21 | 86% | 46.89 | 433 / 504 |
| uterus | 100% | 2871.92 | 170 / 170 | 83% | 25.53 | 382 / 459 |
| breast | 100% | 2937.84 | 457 / 459 | 66% | 15.57 | 741 / 1118 |
| thymus | 85% | 1218.71 | 557 / 653 | 79% | 61.24 | 480 / 605 |
| kidney | 93% | 1842.35 | 83 / 89 | 70% | 30.92 | 631 / 901 |
| skin | 100% | 3652.69 | 1800 / 1809 | 62% | 11.28 | 292 / 472 |
| adrenal gland | 100% | 8052.57 | 258 / 258 | 58% | 16.95 | 133 / 230 |
| lung | 95% | 1797.66 | 547 / 578 | 49% | 14.99 | 569 / 1155 |
| prostate | 100% | 3093.93 | 245 / 245 | 43% | 6.00 | 214 / 502 |
| eye | 0% | 0 | 0 / 0 | 100% | 35.44 | 80 / 80 |
| muscle | 100% | 7091.72 | 803 / 803 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 76.16 | 1 / 1 |
| blood vessel | 100% | 5238.29 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 3023.71 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 4298.05 | 846 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 7% | 66.42 | 23 / 328 | 88% | 35.98 | 157 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 62% | 12.72 | 28 / 45 |
| liver | 0% | 5.56 | 1 / 226 | 14% | 4.29 | 58 / 406 |
| spleen | 9% | 80.00 | 21 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 11.30 | 11 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0060716 | Biological process | labyrinthine layer blood vessel development |
| GO_0016042 | Biological process | lipid catabolic process |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0004435 | Molecular function | phosphatidylinositol phospholipase C activity |
| Gene name | PLCD3 |
| Protein name | Phospholipase C delta 3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) |
| Synonyms | KIAA1964 |
| Description | FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow . Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling (By similarity). . |
| Accessions | Q8N3E9 ENST00000590644.5 F5GXC1 ENST00000619929.5 ENST00000538093.1 ENST00000539433.1 K7EQF2 H0YGF8 |
