PLCG2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	32 studies	33% ± 13%	Explore
endothelial cell	20 studies	37% ± 18%	Explore
memory B cell	17 studies	29% ± 8%	Explore
natural killer cell	17 studies	27% ± 7%	Explore
naive B cell	13 studies	29% ± 10%	Explore
macrophage	12 studies	28% ± 9%	Explore
microglial cell	12 studies	45% ± 19%	Explore
mast cell	12 studies	35% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	33% ± 10%	Explore
plasma cell	10 studies	40% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 5%	Explore
endothelial cell of artery	9 studies	30% ± 14%	Explore
astrocyte	8 studies	45% ± 18%	Explore
endothelial cell of lymphatic vessel	8 studies	28% ± 13%	Explore
non-classical monocyte	7 studies	27% ± 8%	Explore
renal alpha-intercalated cell	7 studies	47% ± 16%	Explore
myeloid cell	7 studies	34% ± 10%	Explore
dendritic cell	7 studies	34% ± 12%	Explore
gamma-delta T cell	7 studies	22% ± 6%	Explore
oligodendrocyte	6 studies	45% ± 18%	Explore
classical monocyte	6 studies	23% ± 8%	Explore
conventional dendritic cell	6 studies	24% ± 10%	Explore
neutrophil	6 studies	36% ± 17%	Explore
monocyte	6 studies	34% ± 17%	Explore
ionocyte	5 studies	48% ± 13%	Explore
GABAergic neuron	5 studies	21% ± 2%	Explore
glutamatergic neuron	5 studies	22% ± 6%	Explore
oligodendrocyte precursor cell	5 studies	47% ± 25%	Explore
CD8-positive, alpha-beta T cell	5 studies	38% ± 26%	Explore
mature NK T cell	5 studies	30% ± 14%	Explore
plasmablast	5 studies	32% ± 16%	Explore
epithelial cell	5 studies	42% ± 10%	Explore
brush cell	5 studies	72% ± 24%	Explore
fibroblast	5 studies	33% ± 5%	Explore
lymphocyte	5 studies	35% ± 7%	Explore
innate lymphoid cell	5 studies	24% ± 8%	Explore
pericyte	5 studies	40% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	27% ± 6%	Explore
abnormal cell	4 studies	35% ± 11%	Explore
precursor B cell	4 studies	26% ± 8%	Explore
immature B cell	4 studies	36% ± 12%	Explore
adipocyte	4 studies	32% ± 7%	Explore
vein endothelial cell	4 studies	38% ± 11%	Explore
ciliated cell	4 studies	24% ± 6%	Explore
smooth muscle cell	4 studies	41% ± 8%	Explore
endothelial cell of vascular tree	4 studies	40% ± 21%	Explore
plasmacytoid dendritic cell	4 studies	23% ± 5%	Explore
interneuron	4 studies	42% ± 29%	Explore
capillary endothelial cell	3 studies	24% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
germinal center B cell	3 studies	39% ± 10%	Explore
IgA plasma cell	3 studies	31% ± 21%	Explore
basal cell	3 studies	42% ± 6%	Explore
regulatory T cell	3 studies	23% ± 7%	Explore
type I pneumocyte	3 studies	25% ± 5%	Explore
alveolar macrophage	3 studies	32% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	33% ± 20%	Explore
peripheral blood	4 studies	32% ± 11%	Explore
lung	4 studies	26% ± 8%	Explore
liver	4 studies	29% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1751.40	651 / 653	94%	5.28	570 / 605
lung	100%	2755.39	578 / 578	93%	6.50	1079 / 1155
kidney	100%	6434.98	89 / 89	91%	24.37	817 / 901
breast	100%	2719.24	459 / 459	89%	6.34	998 / 1118
liver	99%	1569.62	224 / 226	89%	6.24	363 / 406
esophagus	96%	907.55	1387 / 1445	90%	5.44	164 / 183
bladder	100%	1390.81	21 / 21	78%	5.55	395 / 504
uterus	100%	2315.39	170 / 170	75%	3.40	345 / 459
pancreas	74%	513.08	244 / 328	95%	7.46	169 / 178
stomach	93%	852.43	334 / 359	64%	5.75	182 / 286
skin	72%	885.30	1301 / 1809	77%	5.42	363 / 472
intestine	94%	2395.39	908 / 966	55%	3.64	288 / 527
adrenal gland	96%	1135.14	248 / 258	47%	2.79	107 / 230
prostate	96%	981.95	234 / 245	37%	1.18	184 / 502
brain	44%	318.89	1156 / 2642	66%	3.08	462 / 705
ovary	44%	358.04	80 / 180	62%	2.45	267 / 430
adipose	100%	2586.69	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	81.64	29 / 29
peripheral blood	100%	11747.67	929 / 929	0%	0	0 / 0
spleen	100%	10281.77	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	6.02	39 / 45
heart	83%	669.84	712 / 861	0%	0	0 / 0
blood vessel	74%	741.02	991 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	61%	2.14	49 / 80
muscle	18%	100.92	148 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0002224	Biological process	toll-like receptor signaling pathway
GO_0061760	Biological process	antifungal innate immune response
GO_0032959	Biological process	inositol trisphosphate biosynthetic process
GO_1902808	Biological process	positive regulation of cell cycle G1/S phase transition
GO_0046488	Biological process	phosphatidylinositol metabolic process
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0019722	Biological process	calcium-mediated signaling
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0012501	Biological process	programmed cell death
GO_0071396	Biological process	cellular response to lipid
GO_0032747	Biological process	positive regulation of interleukin-23 production
GO_0048678	Biological process	response to axon injury
GO_0010628	Biological process	positive regulation of gene expression
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0010634	Biological process	positive regulation of epithelial cell migration
GO_0019216	Biological process	regulation of lipid metabolic process
GO_0038095	Biological process	Fc-epsilon receptor signaling pathway
GO_1903428	Biological process	positive regulation of reactive oxygen species biosynthetic process
GO_0032733	Biological process	positive regulation of interleukin-10 production
GO_0032481	Biological process	positive regulation of type I interferon production
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0043069	Biological process	negative regulation of programmed cell death
GO_0048015	Biological process	phosphatidylinositol-mediated signaling
GO_0002092	Biological process	positive regulation of receptor internalization
GO_0006661	Biological process	phosphatidylinositol biosynthetic process
GO_0030168	Biological process	platelet activation
GO_0002223	Biological process	stimulatory C-type lectin receptor signaling pathway
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0071277	Biological process	cellular response to calcium ion
GO_1900227	Biological process	positive regulation of NLRP3 inflammasome complex assembly
GO_0002732	Biological process	positive regulation of dendritic cell cytokine production
GO_0035556	Biological process	intracellular signal transduction
GO_0001775	Biological process	cell activation
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0060907	Biological process	positive regulation of macrophage cytokine production
GO_1903721	Biological process	positive regulation of I-kappaB phosphorylation
GO_0002281	Biological process	macrophage activation involved in immune response
GO_0001878	Biological process	response to yeast
GO_0150078	Biological process	positive regulation of neuroinflammatory response
GO_0016055	Biological process	Wnt signaling pathway
GO_0043122	Biological process	regulation of canonical NF-kappaB signal transduction
GO_0060100	Biological process	positive regulation of phagocytosis, engulfment
GO_1990858	Biological process	cellular response to lectin
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0070884	Biological process	regulation of calcineurin-NFAT signaling cascade
GO_0030183	Biological process	B cell differentiation
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0002316	Biological process	follicular B cell differentiation
GO_0009395	Biological process	phospholipid catabolic process
GO_0032587	Cellular component	ruffle membrane
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0070062	Cellular component	extracellular exosome
GO_0097708	Cellular component	intracellular vesicle
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0019901	Molecular function	protein kinase binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0004435	Molecular function	phosphatidylinositol phospholipase C activity
GO_0004629	Molecular function	phospholipase C activity
GO_0097110	Molecular function	scaffold protein binding
GO_0140031	Molecular function	phosphorylation-dependent protein binding
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding

IV. Literature review

[source]

Gene name	PLCG2
Protein name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (EC 3.1.4.11) Phospholipase C gamma 2 Phosphoinositide phospholipase C (EC 3.1.4.11) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Synonyms	hCG_38943
Description	FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. . FUNCTION: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. . FUNCTION: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. .
Accessions	ENST00000569929.5 ENST00000697564.1 ENST00000564138.6 ENST00000697583.1 A0A8V8TL51 P16885 ENST00000565400.5 ENST00000563375.2 A0A8V8TMG4 ENST00000697581.1 ENST00000697561.1 A0A8V8TLG6 H3BPZ3 H3BMT7 A0A8V8TL55 A0A8V8TMP2 ENST00000569523.1 ENST00000697562.1 A0A8V8TLH5 A0A8V8TMQ0 ENST00000697563.1 A0A8V8TL29 ENST00000697584.1 ENST00000697585.1 ENST00000563193.2 ENST00000697582.1 ENST00000697587.1 ENST00000697586.1

PLCG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review