Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 23 studies | 24% ± 7% | |
| classical monocyte | 19 studies | 24% ± 9% | |
| monocyte | 7 studies | 26% ± 9% | |
| non-classical monocyte | 5 studies | 23% ± 7% | |
| myeloid cell | 5 studies | 35% ± 12% | |
| neutrophil | 3 studies | 16% ± 1% | |
| dendritic cell | 3 studies | 26% ± 4% | |
| mononuclear phagocyte | 3 studies | 21% ± 7% | |
| microglial cell | 3 studies | 21% ± 3% |
Insufficient scRNA-seq data for expression of CCR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 1227.21 | 573 / 578 | 91% | 20.34 | 1051 / 1155 |
| breast | 77% | 310.40 | 352 / 459 | 92% | 19.48 | 1034 / 1118 |
| intestine | 82% | 311.44 | 793 / 966 | 72% | 10.01 | 382 / 527 |
| bladder | 76% | 257.67 | 16 / 21 | 70% | 11.57 | 351 / 504 |
| kidney | 60% | 184.74 | 53 / 89 | 81% | 17.09 | 731 / 901 |
| stomach | 51% | 168.53 | 182 / 359 | 80% | 12.65 | 228 / 286 |
| brain | 42% | 154.69 | 1111 / 2642 | 88% | 20.31 | 622 / 705 |
| ovary | 42% | 100.93 | 76 / 180 | 83% | 13.06 | 357 / 430 |
| esophagus | 58% | 195.34 | 844 / 1445 | 63% | 7.12 | 116 / 183 |
| adrenal gland | 86% | 525.46 | 221 / 258 | 34% | 3.32 | 78 / 230 |
| uterus | 45% | 99.94 | 76 / 170 | 69% | 9.13 | 315 / 459 |
| pancreas | 32% | 70.11 | 106 / 328 | 81% | 11.50 | 144 / 178 |
| thymus | 42% | 108.81 | 275 / 653 | 68% | 7.02 | 409 / 605 |
| skin | 15% | 32.69 | 272 / 1809 | 86% | 20.15 | 405 / 472 |
| spleen | 100% | 2803.36 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 4321.53 | 908 / 929 | 0% | 0 | 0 / 0 |
| adipose | 97% | 849.13 | 1163 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 44.67 | 26 / 29 |
| prostate | 48% | 123.58 | 117 / 245 | 35% | 2.54 | 174 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 14.43 | 37 / 45 |
| liver | 41% | 134.69 | 92 / 226 | 40% | 4.08 | 163 / 406 |
| blood vessel | 61% | 317.10 | 819 / 1335 | 0% | 0 | 0 / 0 |
| heart | 45% | 137.09 | 389 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 26% | 2.41 | 21 / 80 |
| muscle | 10% | 18.15 | 84 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0006954 | Biological process | inflammatory response |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0090026 | Biological process | positive regulation of monocyte chemotaxis |
| GO_0006935 | Biological process | chemotaxis |
| GO_0007155 | Biological process | cell adhesion |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0045672 | Biological process | positive regulation of osteoclast differentiation |
| GO_0006955 | Biological process | immune response |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0006887 | Biological process | exocytosis |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0030502 | Biological process | negative regulation of bone mineralization |
| GO_0051928 | Biological process | positive regulation of calcium ion transport |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0009611 | Biological process | response to wounding |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0035717 | Molecular function | chemokine (C-C motif) ligand 7 binding |
| GO_0004435 | Molecular function | phosphatidylinositol phospholipase C activity |
| GO_0016493 | Molecular function | C-C chemokine receptor activity |
| GO_0004950 | Molecular function | chemokine receptor activity |
| GO_0019957 | Molecular function | C-C chemokine binding |
| GO_0071791 | Molecular function | chemokine (C-C motif) ligand 5 binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CCR1 |
| Protein name | Chemokine (C-C motif) receptor 1 C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (HM145) (LD78 receptor) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) |
| Synonyms | SCYAR1 CMKBR1 CMKR1 hCG_15324 |
| Description | FUNCTION: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. |
| Accessions | ENST00000296140.4 P32246 Q5U003 |
