I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enterocyte | 5 studies | 21% ± 4% | |
| epithelial cell | 3 studies | 29% ± 9% | |
| goblet cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enterocyte | 5 studies | 21% ± 4% | |
| epithelial cell | 3 studies | 29% ± 9% | |
| goblet cell | 3 studies | 17% ± 1% |
Insufficient scRNA-seq data for expression of PLCB3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4210.04 | 1445 / 1445 | 100% | 75.37 | 183 / 183 |
| intestine | 100% | 5309.91 | 966 / 966 | 100% | 79.95 | 527 / 527 |
| uterus | 100% | 4159.48 | 170 / 170 | 100% | 56.67 | 459 / 459 |
| skin | 100% | 3655.58 | 1809 / 1809 | 100% | 34.35 | 471 / 472 |
| prostate | 100% | 3026.53 | 245 / 245 | 100% | 29.14 | 500 / 502 |
| bladder | 100% | 2953.00 | 21 / 21 | 99% | 64.54 | 501 / 504 |
| thymus | 100% | 2430.42 | 653 / 653 | 99% | 22.40 | 601 / 605 |
| ovary | 100% | 3273.36 | 180 / 180 | 99% | 27.95 | 426 / 430 |
| lung | 100% | 3546.55 | 578 / 578 | 99% | 42.24 | 1144 / 1155 |
| stomach | 100% | 2206.28 | 359 / 359 | 99% | 71.17 | 283 / 286 |
| breast | 100% | 2525.62 | 459 / 459 | 99% | 35.76 | 1105 / 1118 |
| adrenal gland | 100% | 3934.50 | 258 / 258 | 95% | 42.10 | 219 / 230 |
| kidney | 100% | 2072.94 | 89 / 89 | 95% | 19.24 | 857 / 901 |
| pancreas | 96% | 1026.51 | 316 / 328 | 97% | 54.97 | 173 / 178 |
| brain | 92% | 1086.80 | 2433 / 2642 | 99% | 27.57 | 695 / 705 |
| liver | 79% | 664.69 | 178 / 226 | 64% | 10.98 | 261 / 406 |
| spleen | 100% | 3113.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 58.65 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 94.48 | 1 / 1 |
| adipose | 100% | 2737.91 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3165.18 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1442.34 | 852 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 25.62 | 79 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 15.42 | 26 / 29 |
| muscle | 84% | 785.00 | 671 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 82% | 890.97 | 765 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0046488 | Biological process | phosphatidylinositol metabolic process |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0051209 | Biological process | release of sequestered calcium ion into cytosol |
| GO_0048015 | Biological process | phosphatidylinositol-mediated signaling |
| GO_0016042 | Biological process | lipid catabolic process |
| GO_0003073 | Biological process | regulation of systemic arterial blood pressure |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0016020 | Cellular component | membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0099524 | Cellular component | postsynaptic cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140677 | Molecular function | molecular function activator activity |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0004435 | Molecular function | phosphatidylinositol phospholipase C activity |
| GO_0004629 | Molecular function | phospholipase C activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PLCB3 |
| Protein name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3) |
| Synonyms | |
| Description | FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . |
| Accessions | ENST00000540288.5 [Q01970-1] ENST00000325234.5 [Q01970-2] Q01970 ENST00000279230.12 [Q01970-1] |
