PLCB4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	26 studies	42% ± 21%	Explore
pericyte	12 studies	39% ± 18%	Explore
oligodendrocyte precursor cell	11 studies	40% ± 16%	Explore
smooth muscle cell	11 studies	41% ± 19%	Explore
GABAergic neuron	9 studies	48% ± 18%	Explore
glutamatergic neuron	9 studies	46% ± 23%	Explore
astrocyte	8 studies	31% ± 15%	Explore
fibroblast	8 studies	28% ± 7%	Explore
ciliated cell	7 studies	32% ± 12%	Explore
epithelial cell	7 studies	44% ± 18%	Explore
endothelial cell of artery	7 studies	34% ± 18%	Explore
endothelial cell of lymphatic vessel	7 studies	44% ± 17%	Explore
interneuron	6 studies	56% ± 23%	Explore
amacrine cell	6 studies	49% ± 25%	Explore
retina horizontal cell	6 studies	68% ± 23%	Explore
neuron	5 studies	34% ± 13%	Explore
retinal bipolar neuron	5 studies	40% ± 24%	Explore
cardiac muscle cell	5 studies	48% ± 10%	Explore
vein endothelial cell	4 studies	48% ± 18%	Explore
respiratory goblet cell	4 studies	33% ± 7%	Explore
ionocyte	3 studies	33% ± 10%	Explore
GABAergic interneuron	3 studies	44% ± 16%	Explore
granule cell	3 studies	71% ± 12%	Explore
microglial cell	3 studies	62% ± 12%	Explore
GABAergic amacrine cell	3 studies	65% ± 6%	Explore
OFF-bipolar cell	3 studies	66% ± 26%	Explore
ON-bipolar cell	3 studies	56% ± 22%	Explore
glycinergic amacrine cell	3 studies	59% ± 5%	Explore
rod bipolar cell	3 studies	41% ± 17%	Explore
endothelial cell of vascular tree	3 studies	46% ± 14%	Explore
retinal pigment epithelial cell	3 studies	70% ± 19%	Explore
ependymal cell	3 studies	52% ± 4%	Explore
goblet cell	3 studies	30% ± 11%	Explore
capillary endothelial cell	3 studies	41% ± 9%	Explore
transit amplifying cell	3 studies	41% ± 30%	Explore
mucus secreting cell	3 studies	30% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	36% ± 17%	Explore
eye	5 studies	34% ± 16%	Explore
heart	4 studies	34% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	2163.85	244 / 245	99%	19.00	497 / 502
intestine	99%	2165.88	960 / 966	91%	54.74	481 / 527
thymus	100%	2638.26	651 / 653	88%	26.75	531 / 605
stomach	99%	1777.55	357 / 359	87%	48.57	250 / 286
breast	99%	2222.08	454 / 459	72%	10.96	809 / 1118
esophagus	89%	2593.29	1288 / 1445	63%	11.92	115 / 183
lung	97%	1575.89	561 / 578	51%	7.17	590 / 1155
kidney	74%	723.38	66 / 89	73%	13.78	656 / 901
bladder	100%	2323.10	21 / 21	40%	23.88	201 / 504
skin	89%	1784.27	1614 / 1809	48%	10.86	227 / 472
brain	80%	2399.35	2106 / 2642	56%	4.04	394 / 705
uterus	99%	2095.82	169 / 170	35%	6.28	159 / 459
ovary	53%	539.82	96 / 180	54%	5.07	231 / 430
blood vessel	100%	2596.40	1331 / 1335	0%	0	0 / 0
adipose	99%	1921.77	1189 / 1204	0%	0	0 / 0
heart	97%	1662.50	839 / 861	0%	0	0 / 0
adrenal gland	17%	159.59	45 / 258	66%	34.40	152 / 230
pancreas	7%	46.70	24 / 328	71%	9.33	127 / 178
eye	0%	0	0 / 0	76%	20.77	61 / 80
muscle	50%	329.14	398 / 803	0%	0	0 / 0
spleen	6%	35.01	15 / 241	0%	0	0 / 0
liver	0%	0	0 / 226	4%	0.34	17 / 406
tonsil	0%	0	0 / 0	2%	0.14	1 / 45
peripheral blood	0%	0.84	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0160135	Biological process	phospholipase C-activating endothelin receptor signaling pathway
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0046488	Biological process	phosphatidylinositol metabolic process
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0048015	Biological process	phosphatidylinositol-mediated signaling
GO_0016042	Biological process	lipid catabolic process
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0004629	Molecular function	phospholipase C activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0004435	Molecular function	phosphatidylinositol phospholipase C activity

IV. Literature review

[source]

Gene name	PLCB4
Protein name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4) Phospholipase C beta 4 Phosphoinositide phospholipase C (EC 3.1.4.11) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)
Synonyms
Description	FUNCTION: Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development . . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. .
Accessions	ENST00000693752.1 [Q15147-4] A0A8I5KYY7 ENST00000688656.1 [Q15147-1] ENST00000441846.5 A0A8I5KPQ9 ENST00000693492.1 ENST00000684997.1 ENST00000687299.1 ENST00000688837.1 ENST00000685859.1 [Q15147-1] A0A8I5KW09 ENST00000687765.1 A0A8J8Z831 ENST00000693502.1 ENST00000378473.9 A0A8I5KR92 ENST00000685568.1 A0A8I5KWR8 ENST00000686893.1 ENST00000689910.1 [Q15147-1] ENST00000685823.1 [Q15147-5] A0A8I5KRP3 ENST00000685110.1 [Q15147-1] ENST00000688325.1 ENST00000685482.1 A0A8I5KVM8 ENST00000685298.1 ENST00000689010.1 ENST00000693544.1 A0A8I5KX82 ENST00000414679.7 B1AJW3 ENST00000685148.1 ENST00000686253.1 A0A8I5QJE7 A0A8I5KPD4 ENST00000686871.1 [Q15147-4] ENST00000686163.1 B1AJW1 ENST00000690729.1 A0A8I5KXW3 A0A8I5QL35 ENST00000686976.1 [Q15147-4] ENST00000378493.6 [Q15147-1] A0A8I5KRK2 ENST00000693090.1 ENST00000492632.5 A0A8I5KQI1 ENST00000686117.1 ENST00000692085.1 ENST00000416836.5 ENST00000378501.3 [Q15147-4] Q15147 A0A8I5KXD7 A0A8I5KRA0 A0A8I5QJ53 A0A7P0MRI8 ENST00000692395.1 ENST00000278655.9 A0A8I5KQ87 ENST00000693005.1 [Q15147-1] A0A8I5KQZ0 A0A8I5KS50 ENST00000691007.1 ENST00000689392.1 ENST00000691112.1 ENST00000687446.1 ENST00000686584.1 A0A8I5KX58 ENST00000685310.1 [Q15147-1] ENST00000690960.1 A0A8I5KQF5 ENST00000686313.1 [Q15147-4] A0A8I5KXT9 ENST00000693160.1

PLCB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review