PLCB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	31 studies	50% ± 19%	Explore
astrocyte	16 studies	56% ± 24%	Explore
pericyte	14 studies	44% ± 20%	Explore
smooth muscle cell	13 studies	36% ± 11%	Explore
oligodendrocyte precursor cell	13 studies	71% ± 22%	Explore
glutamatergic neuron	12 studies	79% ± 18%	Explore
GABAergic neuron	11 studies	73% ± 22%	Explore
fibroblast	11 studies	43% ± 18%	Explore
capillary endothelial cell	9 studies	27% ± 8%	Explore
endothelial cell of artery	9 studies	32% ± 15%	Explore
microglial cell	9 studies	33% ± 20%	Explore
oligodendrocyte	8 studies	31% ± 22%	Explore
T cell	7 studies	25% ± 9%	Explore
neuron	7 studies	49% ± 25%	Explore
retinal ganglion cell	7 studies	74% ± 23%	Explore
adipocyte	7 studies	37% ± 13%	Explore
mesothelial cell	7 studies	49% ± 23%	Explore
interneuron	6 studies	66% ± 23%	Explore
vein endothelial cell	6 studies	41% ± 25%	Explore
natural killer cell	6 studies	37% ± 15%	Explore
endothelial cell of lymphatic vessel	5 studies	40% ± 9%	Explore
granule cell	4 studies	61% ± 22%	Explore
mucosal invariant T cell	4 studies	32% ± 20%	Explore
Mueller cell	4 studies	40% ± 10%	Explore
amacrine cell	4 studies	46% ± 21%	Explore
mast cell	4 studies	23% ± 6%	Explore
monocyte	4 studies	36% ± 10%	Explore
kidney loop of Henle epithelial cell	4 studies	58% ± 33%	Explore
hepatic stellate cell	3 studies	48% ± 18%	Explore
GABAergic interneuron	3 studies	86% ± 11%	Explore
epithelial cell	3 studies	51% ± 27%	Explore
macrophage	3 studies	31% ± 19%	Explore
progenitor cell	3 studies	53% ± 31%	Explore
CD4-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore
CD8-positive, alpha-beta T cell	3 studies	21% ± 5%	Explore
GABAergic amacrine cell	3 studies	37% ± 9%	Explore
glycinergic amacrine cell	3 studies	36% ± 7%	Explore
basal cell	3 studies	33% ± 21%	Explore
endothelial cell of vascular tree	3 studies	71% ± 13%	Explore
ependymal cell	3 studies	41% ± 8%	Explore
lymphocyte	3 studies	39% ± 10%	Explore
mucus secreting cell	3 studies	47% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	54% ± 25%	Explore
heart	4 studies	28% ± 6%	Explore
adipose	3 studies	41% ± 10%	Explore
kidney	3 studies	30% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	3771.18	2619 / 2642	95%	15.33	670 / 705
prostate	100%	1739.75	245 / 245	90%	5.24	451 / 502
esophagus	82%	1962.63	1192 / 1445	89%	7.02	162 / 183
bladder	100%	2244.90	21 / 21	70%	3.65	355 / 504
lung	90%	781.24	523 / 578	78%	4.72	901 / 1155
stomach	96%	1142.47	343 / 359	72%	4.42	207 / 286
pancreas	96%	741.80	315 / 328	63%	2.63	112 / 178
adrenal gland	100%	1424.00	258 / 258	58%	2.75	133 / 230
breast	99%	1160.17	454 / 459	57%	3.99	640 / 1118
kidney	84%	896.19	75 / 89	68%	8.02	616 / 901
uterus	99%	1082.68	168 / 170	53%	2.81	242 / 459
intestine	82%	2117.77	793 / 966	62%	3.17	329 / 527
ovary	63%	456.37	113 / 180	70%	3.68	300 / 430
thymus	86%	632.73	563 / 653	29%	1.33	178 / 605
ureter	0%	0	0 / 0	100%	2.12	1 / 1
adipose	99%	1233.07	1192 / 1204	0%	0	0 / 0
liver	39%	213.11	89 / 226	49%	2.55	199 / 406
skin	44%	268.51	798 / 1809	42%	2.25	200 / 472
muscle	78%	646.53	624 / 803	0%	0	0 / 0
heart	76%	636.73	654 / 861	0%	0	0 / 0
blood vessel	68%	527.22	911 / 1335	0%	0	0 / 0
spleen	50%	254.23	121 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	33%	1.15	15 / 45
peripheral blood	7%	34.51	63 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000560	Biological process	positive regulation of CD24 production
GO_0035723	Biological process	interleukin-15-mediated signaling pathway
GO_0046488	Biological process	phosphatidylinositol metabolic process
GO_0007213	Biological process	G protein-coupled acetylcholine receptor signaling pathway
GO_2000344	Biological process	positive regulation of acrosome reaction
GO_0080154	Biological process	regulation of fertilization
GO_0007612	Biological process	learning
GO_0099178	Biological process	regulation of retrograde trans-synaptic signaling by endocanabinoid
GO_0007207	Biological process	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0048009	Biological process	insulin-like growth factor receptor signaling pathway
GO_0031161	Biological process	phosphatidylinositol catabolic process
GO_0007165	Biological process	signal transduction
GO_0032735	Biological process	positive regulation of interleukin-12 production
GO_1990806	Biological process	ligand-gated ion channel signaling pathway
GO_0048639	Biological process	positive regulation of developmental growth
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0070498	Biological process	interleukin-1-mediated signaling pathway
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0048015	Biological process	phosphatidylinositol-mediated signaling
GO_0060466	Biological process	activation of meiosis involved in egg activation
GO_1904117	Biological process	cellular response to vasopressin
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0040019	Biological process	positive regulation of embryonic development
GO_1904637	Biological process	cellular response to ionomycin
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0008277	Biological process	regulation of G protein-coupled receptor signaling pathway
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_2000438	Biological process	negative regulation of monocyte extravasation
GO_1905631	Biological process	cellular response to glyceraldehyde
GO_0035722	Biological process	interleukin-12-mediated signaling pathway
GO_0007613	Biological process	memory
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0099170	Biological process	postsynaptic modulation of chemical synaptic transmission
GO_0021987	Biological process	cerebral cortex development
GO_1902618	Biological process	cellular response to fluoride
GO_1903140	Biological process	regulation of establishment of endothelial barrier
GO_0007215	Biological process	glutamate receptor signaling pathway
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0032957	Biological process	inositol trisphosphate metabolic process
GO_0045444	Biological process	fat cell differentiation
GO_0099105	Biological process	ion channel modulating, G protein-coupled receptor signaling pathway
GO_0098978	Cellular component	glutamatergic synapse
GO_0016607	Cellular component	nuclear speck
GO_0070062	Cellular component	extracellular exosome
GO_0098982	Cellular component	GABA-ergic synapse
GO_0005829	Cellular component	cytosol
GO_0099524	Cellular component	postsynaptic cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0042802	Molecular function	identical protein binding
GO_0005096	Molecular function	GTPase activator activity
GO_0004435	Molecular function	phosphatidylinositol phospholipase C activity
GO_0004629	Molecular function	phospholipase C activity
GO_0005521	Molecular function	lamin binding
GO_0005516	Molecular function	calmodulin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PLCB1
Protein name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) Phospholipase C beta 1 Phosphoinositide phospholipase C (EC 3.1.4.11) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (EC 3.1.4.11)
Synonyms	KIAA0581
Description	FUNCTION: Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors . Regulates the function of the endothelial barrier. . FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. .
Accessions	ENST00000635929.1 ENST00000626966.2 A0A1B0GVT0 ENST00000378641.7 [Q9NQ66-2] A0A0D9SFJ4 A0A0D9SFE7 ENST00000625874.2 Q9NQ66 A0A1B0GW62 A0A1B0GTC7 ENST00000475958.1 ENST00000637919.1 B1AK73 ENST00000378637.6 [Q9NQ66-2] ENST00000629992.2 ENST00000637422.1 ENST00000437439.2 Q8IV92 Q8IV91 A0A1B0GW45 A0A0D9SFA6 ENST00000637204.1 A0A1B0GVC1 ENST00000404098.6 A0A0D9SGI7 ENST00000636319.1 ENST00000637935.1 ENST00000487210.5 ENST00000630495.2 ENST00000338037.11 [Q9NQ66-1] A0A0D9SF51 A0A0D9SG17 ENST00000628239.2 H0YCJ2 A0A1B0GWB6 ENST00000439627.2

PLCB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review