PLCZ1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLCZ1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLCZ1 at tissue level.

III. Associated gene sets

GO_0035556Biological processintracellular signal transduction
GO_0007343Biological processegg activation
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0060470Biological processpositive regulation of cytosolic calcium ion concentration involved in egg activation
GO_0006816Biological processcalcium ion transport
GO_0016042Biological processlipid catabolic process
GO_0005730Cellular componentnucleolus
GO_0061827Cellular componentsperm head
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0045120Cellular componentpronucleus
GO_0005634Cellular componentnucleus
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005509Molecular functioncalcium ion binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0004435Molecular functionphosphatidylinositol phospholipase C activity

IV. Literature review

[source]
Gene namePLCZ1
Protein namePhospholipase C zeta 1
Phosphoinositide phospholipase C (EC 3.1.4.11)
phosphoinositide phospholipase C (EC 3.1.4.11)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-zeta-1) (Phospholipase C-zeta-1) (PLC-zeta-1) (Testis-development protein NYD-SP27)
Synonyms
DescriptionFUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. .

FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. .

FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. .

AccessionsH0YGY7
F5H474
ENST00000536023.1
ENST00000540270.5
ENST00000648272.1
ENST00000539207.5
A0A3B3ISW9
ENST00000541966.5
Q8N7S5
F5H3L4
ENST00000538330.5
Q86YW0
F5H2D7
H0YH40
ENST00000318197.10
ENST00000540421.5
ENST00000535429.1
ENST00000539072.5
ENST00000534932.5
ENST00000539875.5 [Q86YW0-2]
ENST00000543219.5
F5GYE4
ENST00000543242.5
ENST00000266505.12 [Q86YW0-1]
F5H828
H0YFH9
F5GZK3
H0YGH7