Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 33 studies | 35% ± 18% | |
| smooth muscle cell | 22 studies | 32% ± 12% | |
| fibroblast | 15 studies | 27% ± 10% | |
| connective tissue cell | 8 studies | 29% ± 12% | |
| myofibroblast cell | 4 studies | 40% ± 6% | |
| endothelial cell | 4 studies | 24% ± 3% | |
| cardiac muscle cell | 4 studies | 17% ± 2% | |
| muscle cell | 3 studies | 25% ± 5% |
Insufficient scRNA-seq data for expression of EDNRA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3634.75 | 244 / 245 | 95% | 26.63 | 476 / 502 |
| breast | 98% | 1764.20 | 450 / 459 | 95% | 29.76 | 1062 / 1118 |
| lung | 100% | 3385.58 | 577 / 578 | 87% | 19.49 | 1001 / 1155 |
| thymus | 99% | 1508.29 | 646 / 653 | 85% | 17.80 | 512 / 605 |
| uterus | 100% | 5311.84 | 170 / 170 | 67% | 17.15 | 307 / 459 |
| bladder | 100% | 2284.90 | 21 / 21 | 60% | 9.25 | 304 / 504 |
| esophagus | 79% | 782.88 | 1140 / 1445 | 77% | 13.55 | 140 / 183 |
| ovary | 100% | 4662.27 | 180 / 180 | 53% | 7.71 | 228 / 430 |
| stomach | 60% | 861.26 | 216 / 359 | 79% | 17.03 | 227 / 286 |
| intestine | 59% | 486.37 | 572 / 966 | 74% | 12.14 | 389 / 527 |
| kidney | 65% | 609.29 | 58 / 89 | 63% | 18.76 | 567 / 901 |
| skin | 86% | 791.54 | 1549 / 1809 | 34% | 5.54 | 159 / 472 |
| adrenal gland | 66% | 445.81 | 171 / 258 | 46% | 7.91 | 105 / 230 |
| brain | 19% | 98.59 | 500 / 2642 | 88% | 20.75 | 620 / 705 |
| blood vessel | 100% | 3018.30 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 2038.93 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| heart | 97% | 2207.15 | 837 / 861 | 0% | 0 | 0 / 0 |
| spleen | 97% | 1043.49 | 234 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 27.35 | 13 / 328 | 92% | 30.38 | 164 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 7.77 | 27 / 45 |
| muscle | 35% | 200.90 | 283 / 803 | 0% | 0 | 0 / 0 |
| liver | 9% | 45.64 | 21 / 226 | 20% | 2.01 | 82 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 2.23 | 4 / 29 |
| eye | 0% | 0 | 0 / 0 | 13% | 1.06 | 10 / 80 |
| peripheral blood | 0% | 1.64 | 3 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006939 | Biological process | smooth muscle contraction |
| GO_0030202 | Biological process | heparin metabolic process |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0048485 | Biological process | sympathetic nervous system development |
| GO_0060385 | Biological process | axonogenesis involved in innervation |
| GO_0002027 | Biological process | regulation of heart rate |
| GO_0030878 | Biological process | thyroid gland development |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0097152 | Biological process | mesenchymal cell apoptotic process |
| GO_0003220 | Biological process | left ventricular cardiac muscle tissue morphogenesis |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0035050 | Biological process | embryonic heart tube development |
| GO_0014824 | Biological process | artery smooth muscle contraction |
| GO_0042310 | Biological process | vasoconstriction |
| GO_0042415 | Biological process | norepinephrine metabolic process |
| GO_1903537 | Biological process | meiotic cell cycle process involved in oocyte maturation |
| GO_0048484 | Biological process | enteric nervous system development |
| GO_0071806 | Biological process | protein transmembrane transport |
| GO_0007585 | Biological process | respiratory gaseous exchange by respiratory system |
| GO_0070294 | Biological process | renal sodium ion absorption |
| GO_1904888 | Biological process | cranial skeletal system development |
| GO_2001259 | Biological process | positive regulation of cation channel activity |
| GO_0035904 | Biological process | aorta development |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0071372 | Biological process | cellular response to follicle-stimulating hormone stimulus |
| GO_1903210 | Biological process | podocyte apoptotic process |
| GO_0007165 | Biological process | signal transduction |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0055078 | Biological process | sodium ion homeostasis |
| GO_0097084 | Biological process | vascular associated smooth muscle cell development |
| GO_0010737 | Biological process | protein kinase A signaling |
| GO_0072011 | Biological process | glomerular endothelium development |
| GO_0050905 | Biological process | neuromuscular process |
| GO_0097492 | Biological process | sympathetic neuron axon guidance |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0048706 | Biological process | embryonic skeletal system development |
| GO_0060324 | Biological process | face development |
| GO_0061028 | Biological process | establishment of endothelial barrier |
| GO_0010467 | Biological process | gene expression |
| GO_0042474 | Biological process | middle ear morphogenesis |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0086101 | Biological process | endothelin receptor signaling pathway involved in heart process |
| GO_0016322 | Biological process | neuron remodeling |
| GO_0014034 | Biological process | neural crest cell fate commitment |
| GO_0003357 | Biological process | noradrenergic neuron differentiation |
| GO_0003207 | Biological process | cardiac chamber formation |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0007190 | Biological process | activation of adenylate cyclase activity |
| GO_0034599 | Biological process | cellular response to oxidative stress |
| GO_0007005 | Biological process | mitochondrion organization |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0048675 | Biological process | axon extension |
| GO_0001975 | Biological process | response to amphetamine |
| GO_0003253 | Biological process | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| GO_0009611 | Biological process | response to wounding |
| GO_0072112 | Biological process | podocyte differentiation |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0003094 | Biological process | glomerular filtration |
| GO_0071373 | Biological process | cellular response to luteinizing hormone stimulus |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0044751 | Biological process | cellular response to human chorionic gonadotropin stimulus |
| GO_1902287 | Biological process | semaphorin-plexin signaling pathway involved in axon guidance |
| GO_1905871 | Biological process | regulation of protein localization to cell leading edge |
| GO_0097018 | Biological process | renal albumin absorption |
| GO_0048066 | Biological process | developmental pigmentation |
| GO_1905144 | Biological process | response to acetylcholine |
| GO_0003228 | Biological process | atrial cardiac muscle tissue development |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0086100 | Biological process | endothelin receptor signaling pathway |
| GO_0061626 | Biological process | pharyngeal arch artery morphogenesis |
| GO_0010827 | Biological process | regulation of glucose transmembrane transport |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0004435 | Molecular function | phosphatidylinositol phospholipase C activity |
| GO_0004962 | Molecular function | endothelin receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EDNRA |
| Protein name | Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR) |
| Synonyms | ETA ETRA |
| Description | FUNCTION: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| Accessions | ENST00000358556.8 [P25101-4] ENST00000506066.1 [P25101-4] ENST00000510697.5 [P25101-3] P25101 ENST00000511804.5 [P25101-5] ENST00000651419.1 [P25101-1] ENST00000324300.10 [P25101-1] ENST00000648866.1 [P25101-5] |
