Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 2082.42 | 578 / 578 | 91% | 115.75 | 1048 / 1155 |
| stomach | 87% | 720.15 | 312 / 359 | 68% | 77.15 | 194 / 286 |
| prostate | 86% | 612.98 | 211 / 245 | 67% | 36.12 | 335 / 502 |
| uterus | 71% | 305.90 | 120 / 170 | 79% | 140.85 | 361 / 459 |
| thymus | 85% | 703.57 | 555 / 653 | 63% | 68.19 | 383 / 605 |
| breast | 63% | 405.92 | 289 / 459 | 81% | 101.29 | 906 / 1118 |
| kidney | 58% | 372.70 | 52 / 89 | 81% | 113.28 | 726 / 901 |
| liver | 77% | 391.69 | 175 / 226 | 50% | 42.08 | 205 / 406 |
| intestine | 63% | 865.75 | 609 / 966 | 65% | 50.76 | 341 / 527 |
| bladder | 62% | 626.24 | 13 / 21 | 64% | 114.35 | 321 / 504 |
| esophagus | 45% | 176.18 | 645 / 1445 | 64% | 57.95 | 117 / 183 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 520.02 | 29 / 29 |
| spleen | 100% | 6138.93 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 33.75 | 1 / 1 |
| peripheral blood | 100% | 15148.19 | 928 / 929 | 0% | 0 | 0 / 0 |
| ovary | 26% | 128.06 | 47 / 180 | 69% | 51.58 | 295 / 430 |
| pancreas | 16% | 53.49 | 53 / 328 | 78% | 80.51 | 138 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 253.07 | 41 / 45 |
| skin | 12% | 37.60 | 209 / 1809 | 76% | 166.10 | 361 / 472 |
| adipose | 82% | 661.15 | 989 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 46% | 227.16 | 118 / 258 | 20% | 11.07 | 45 / 230 |
| blood vessel | 50% | 350.45 | 668 / 1335 | 0% | 0 | 0 / 0 |
| heart | 28% | 105.54 | 241 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 25% | 29.42 | 20 / 80 |
| brain | 11% | 47.64 | 281 / 2642 | 13% | 6.70 | 91 / 705 |
| muscle | 3% | 10.01 | 28 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050796 | Biological process | regulation of insulin secretion |
| GO_0010536 | Biological process | positive regulation of activation of Janus kinase activity |
| GO_0045071 | Biological process | negative regulation of viral genome replication |
| GO_0006954 | Biological process | inflammatory response |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0006935 | Biological process | chemotaxis |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0045744 | Biological process | negative regulation of G protein-coupled receptor signaling pathway |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0045089 | Biological process | positive regulation of innate immune response |
| GO_0070098 | Biological process | chemokine-mediated signaling pathway |
| GO_0070234 | Biological process | positive regulation of T cell apoptotic process |
| GO_0050863 | Biological process | regulation of T cell activation |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0043922 | Biological process | negative regulation by host of viral transcription |
| GO_0071347 | Biological process | cellular response to interleukin-1 |
| GO_0031328 | Biological process | positive regulation of cellular biosynthetic process |
| GO_0014911 | Biological process | positive regulation of smooth muscle cell migration |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0002676 | Biological process | regulation of chronic inflammatory response |
| GO_2000503 | Biological process | positive regulation of natural killer cell chemotaxis |
| GO_0034112 | Biological process | positive regulation of homotypic cell-cell adhesion |
| GO_2000406 | Biological process | positive regulation of T cell migration |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0010820 | Biological process | positive regulation of T cell chemotaxis |
| GO_0033634 | Biological process | positive regulation of cell-cell adhesion mediated by integrin |
| GO_0045070 | Biological process | positive regulation of viral genome replication |
| GO_0006887 | Biological process | exocytosis |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0048246 | Biological process | macrophage chemotaxis |
| GO_0071346 | Biological process | cellular response to type II interferon |
| GO_0070233 | Biological process | negative regulation of T cell apoptotic process |
| GO_0045948 | Biological process | positive regulation of translational initiation |
| GO_2000110 | Biological process | negative regulation of macrophage apoptotic process |
| GO_0070100 | Biological process | negative regulation of chemokine-mediated signaling pathway |
| GO_0009615 | Biological process | response to virus |
| GO_0090026 | Biological process | positive regulation of monocyte chemotaxis |
| GO_0045785 | Biological process | positive regulation of cell adhesion |
| GO_0045745 | Biological process | positive regulation of G protein-coupled receptor signaling pathway |
| GO_0010759 | Biological process | positive regulation of macrophage chemotaxis |
| GO_0031584 | Biological process | activation of phospholipase D activity |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0048245 | Biological process | eosinophil chemotaxis |
| GO_0051928 | Biological process | positive regulation of calcium ion transport |
| GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO_0002548 | Biological process | monocyte chemotaxis |
| GO_0044344 | Biological process | cellular response to fibroblast growth factor stimulus |
| GO_0042119 | Biological process | neutrophil activation |
| GO_0007159 | Biological process | leukocyte cell-cell adhesion |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016004 | Molecular function | phospholipase activator activity |
| GO_0031730 | Molecular function | CCR5 chemokine receptor binding |
| GO_0048020 | Molecular function | CCR chemokine receptor binding |
| GO_0031729 | Molecular function | CCR4 chemokine receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0004435 | Molecular function | phosphatidylinositol phospholipase C activity |
| GO_0042379 | Molecular function | chemokine receptor binding |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0030298 | Molecular function | receptor signaling protein tyrosine kinase activator activity |
| GO_0008009 | Molecular function | chemokine activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0031726 | Molecular function | CCR1 chemokine receptor binding |
| GO_0046817 | Molecular function | chemokine receptor antagonist activity |
| Gene name | CCL5 |
| Protein name | C-C motif chemokine C-C motif chemokine ligand 5 C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)] C-C motif chemokine 5 |
| Synonyms | SCYA5 hCG_32592 D17S136E |
| Description | FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) . May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells . . |
| Accessions | A0A494C1Q1 ENST00000651122.1 ENST00000632752.1 P13501 ENST00000605509.2 A0A075B7C5 ENST00000618639.4 ENST00000605140.6 ENST00000613606.2 D0EI67 |
