CASR | OmnibusX

Name	Number of supported studies	Average coverage
kidney loop of Henle epithelial cell	4 studies	49% ± 28%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	1477.95	328 / 328	79%	8.65	140 / 178
kidney	100%	2397.30	89 / 89	23%	1.12	211 / 901
liver	87%	36.52	197 / 226	5%	0.31	22 / 406
spleen	84%	61.11	203 / 241	0%	0	0 / 0
ovary	76%	144.83	136 / 180	7%	0.19	30 / 430
bladder	76%	81.33	16 / 21	2%	0.08	11 / 504
stomach	64%	18.12	229 / 359	1%	0.05	4 / 286
intestine	49%	13.60	477 / 966	4%	0.35	21 / 527
thymus	38%	207.41	247 / 653	2%	0.09	11 / 605
prostate	35%	6.42	85 / 245	0%	0	0 / 502
peripheral blood	31%	21.97	289 / 929	0%	0	0 / 0
adrenal gland	28%	4.36	73 / 258	1%	0.27	3 / 230
lung	22%	4.43	127 / 578	5%	0.34	54 / 1155
brain	17%	7.36	450 / 2642	0%	0	0 / 705
esophagus	9%	1.15	125 / 1445	2%	0.21	3 / 183
skin	3%	0.35	53 / 1809	1%	0.03	5 / 472
adipose	4%	0.82	44 / 1204	0%	0	0 / 0
uterus	2%	0.31	4 / 170	1%	0.14	5 / 459
breast	3%	0.36	14 / 459	0%	0.00	1 / 1118
eye	0%	0	0 / 0	3%	0.05	2 / 80
tonsil	0%	0	0 / 0	2%	0.07	1 / 45
blood vessel	2%	0.26	26 / 1335	0%	0	0 / 0
muscle	1%	0.12	10 / 803	0%	0	0 / 0
heart	1%	0.07	6 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1901653	Biological process	cellular response to peptide
GO_0007254	Biological process	JNK cascade
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0002931	Biological process	response to ischemia
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0048754	Biological process	branching morphogenesis of an epithelial tube
GO_0051924	Biological process	regulation of calcium ion transport
GO_0071305	Biological process	cellular response to vitamin D
GO_0007635	Biological process	chemosensory behavior
GO_0035729	Biological process	cellular response to hepatocyte growth factor stimulus
GO_0010628	Biological process	positive regulation of gene expression
GO_0045907	Biological process	positive regulation of vasoconstriction
GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0070509	Biological process	calcium ion import
GO_0071774	Biological process	response to fibroblast growth factor
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0071404	Biological process	cellular response to low-density lipoprotein particle stimulus
GO_0060613	Biological process	fat pad development
GO_1902476	Biological process	chloride transmembrane transport
GO_0007193	Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0001503	Biological process	ossification
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0042311	Biological process	vasodilation
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0032782	Biological process	bile acid secretion
GO_0090280	Biological process	positive regulation of calcium ion import
GO_0005513	Biological process	detection of calcium ion
GO_0071456	Biological process	cellular response to hypoxia
GO_0016323	Cellular component	basolateral plasma membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0043679	Cellular component	axon terminus
GO_0043025	Cellular component	neuronal cell body
GO_0009986	Cellular component	cell surface
GO_0042803	Molecular function	protein homodimerization activity
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0019901	Molecular function	protein kinase binding
GO_0005178	Molecular function	integrin binding
GO_0004435	Molecular function	phosphatidylinositol phospholipase C activity
GO_0016597	Molecular function	amino acid binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CASR
Protein name	Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) Calcium sensing receptor Extracellular calcium-sensing receptor
Synonyms	PCAR1 GPRC2A
Description	FUNCTION: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis . Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system . The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation . .
Accessions	Q2F3K5 Q2F3K6 P41180 Q2F3K1 Q2F3K3 Q2F3K4 B6VB31 A0A1X7SBX3 ENST00000639785.2 [P41180-1] Q2F3K2 ENST00000490131.7 ENST00000498619.4 [P41180-2] ENST00000638421.1 [P41180-1] Q86UN7

CASR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review