PLCL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007214Biological processgamma-aminobutyric acid signaling pathway
GO_0032228Biological processregulation of synaptic transmission, GABAergic
GO_0035556Biological processintracellular signal transduction
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0006629Biological processlipid metabolic process
GO_0005737Cellular componentcytoplasm
GO_0004629Molecular functionphospholipase C activity
GO_0004435Molecular functionphosphatidylinositol phospholipase C activity

IV. Literature review

[source]
Gene namePLCL1
Protein nameInactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP)
Phosphoinositide phospholipase C (EC 3.1.4.11)
Phospholipase C like 1 (inactive)
Synonyms
DescriptionFUNCTION: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. .

AccessionsENST00000435320.1
ENST00000428675.6 [Q15111-1]
F8WAR2
ENST00000487695.6
Q15111
H3BUD4